このアイテムのアクセス数: 140
このアイテムのファイル:
| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.bmcl.2021.128103.pdf | 1.61 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
| DCフィールド | 値 | 言語 |
|---|---|---|
| dc.contributor.author | Kuroki, Kakeru | en |
| dc.contributor.author | Sakai, Takayuki | en |
| dc.contributor.author | Masuda, Toshihiro | en |
| dc.contributor.author | Kawano, Kenichi | en |
| dc.contributor.author | Futaki, Shiroh | en |
| dc.contributor.alternative | 黒木, 翔 | ja |
| dc.contributor.alternative | 阪井, 貴之 | ja |
| dc.contributor.alternative | 益田, 俊博 | ja |
| dc.contributor.alternative | 河野, 健一 | ja |
| dc.contributor.alternative | 二木, 史朗 | ja |
| dc.date.accessioned | 2022-01-07T06:17:34Z | - |
| dc.date.available | 2022-01-07T06:17:34Z | - |
| dc.date.issued | 2021-07 | - |
| dc.identifier.uri | http://hdl.handle.net/2433/267223 | - |
| dc.description.abstract | EpN18 is a curvature-inducing peptide, which loosens lipid packing upon interaction with the cell membrane, and facilitates cell-membrane penetration by arginine-rich cell-penetrating peptides, including octaarginine (R8). In the present study, we conjugated the N-terminal of EpN18 with a pyrenebutyryl (pBu) moiety, which acts as an anchoring unit that increases membrane interactions. Enhanced lipid-packing loosening and cytosolic translocation of R8 were observed by the pBu anchoring of EpN18. | en |
| dc.language.iso | eng | - |
| dc.publisher | Elsevier BV | en |
| dc.rights | © 2021. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license. | en |
| dc.rights | The full-text file will be made open to the public on 1 July 2023 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
| dc.rights | This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | en |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
| dc.subject | Curvature-inducing peptide | en |
| dc.subject | Octaarginine | en |
| dc.subject | Cell membrane translocation | en |
| dc.subject | Pyrenebutyric acid | en |
| dc.subject | Lipid packing loosening | en |
| dc.title | Membrane anchoring of a curvature-inducing peptide, EpN18, promotes membrane translocation of octaarginine | en |
| dc.type | journal article | - |
| dc.type.niitype | Journal Article | - |
| dc.identifier.jtitle | Bioorganic and Medicinal Chemistry Letters | en |
| dc.identifier.volume | 43 | - |
| dc.relation.doi | 10.1016/j.bmcl.2021.128103 | - |
| dc.textversion | author | - |
| dc.identifier.artnum | 128103 | - |
| dc.identifier.pmid | 33984474 | - |
| dcterms.accessRights | open access | - |
| datacite.date.available | 2023-07-01 | - |
| datacite.awardNumber | 18H04547 | - |
| datacite.awardNumber | 18H04017 | - |
| datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-18H04547/ | - |
| datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H04017/ | - |
| dc.identifier.pissn | 0960-894X | - |
| dc.identifier.eissn | 1464-3405 | - |
| jpcoar.funderName | 日本学術振興会 | ja |
| jpcoar.funderName | 日本学術振興会 | ja |
| jpcoar.awardTitle | 生体膜の曲率・脂質パッキング状態変化を誘起する機能性ペプチド | ja |
| jpcoar.awardTitle | 生理活性タンパク質の細胞内移送の新機軸 | ja |
| 出現コレクション: | 学術雑誌掲載論文等 | |
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