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dc.contributor.author | Taniguchi, Masashi | en |
dc.contributor.author | Ikezoe, Tome | en |
dc.contributor.author | Kamitani, Tsukasa | en |
dc.contributor.author | Tsuboyama, Tadao | en |
dc.contributor.author | Ito, Hiromu | en |
dc.contributor.author | Matsuda, Shuichi | en |
dc.contributor.author | Tabara, Yasuharu | en |
dc.contributor.author | Matsuda, Fumihiko | en |
dc.contributor.author | Ichihashi, Noriaki | en |
dc.contributor.alternative | 谷口, 匡史 | ja |
dc.contributor.alternative | 池添, 冬芽 | ja |
dc.contributor.alternative | 紙谷, 司 | ja |
dc.contributor.alternative | 坪山, 直生 | ja |
dc.contributor.alternative | 伊藤, 宣 | ja |
dc.contributor.alternative | 松田, 秀一 | ja |
dc.contributor.alternative | 田原, 康玄 | ja |
dc.contributor.alternative | 松田, 文彦 | ja |
dc.contributor.alternative | 市橋, 則明 | ja |
dc.date.accessioned | 2022-02-08T07:22:43Z | - |
dc.date.available | 2022-02-08T07:22:43Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.uri | http://hdl.handle.net/2433/267881 | - |
dc.description.abstract | INTRODUCTION/OBJECTIVES: To test the hypothesis that greater extracellular-to-intracellular water (ECW/ICW) ratios in lower-limb muscles are associated with worsened functional abilities in patients with knee osteoarthritis (OA). METHODS: We analyzed data from 787 participants (82.2% female; mean age, 69.6 ± 5.3 years) from the Nagahama Prospective Cohort who were ≥60 years old and had radiographically confirmed bilateral knee OA. The Knee Scoring System (KSS) was used to assess functional abilities. Lower-limb ECW/ICW ratios and skeletal mass index values were determined with multi-frequency bioelectrical impedance analysis (BIA). Multiple linear regression analysis was used to test for associations between ECW/ICW ratios and functional abilities. Subgroup analyses based on OA severities and symptomaticity were also conducted. RESULTS: Increased ECW/ICW ratios were associated with a 4.38-point decrease in the KSS function scores (95% confidence interval [CI], 3.15-5.62 points) after adjusting for covariates. This association varied according to the degree of knee symptoms, especially in individuals with radiologically mild OA. ECW/ICW ratios in individuals with asymptomatic mild OA were associated with a 2.14-point decrease in the KSS function score (95% CI, 0.32-3.96 points), whereas those in individuals with severe symptomatic mild OA were associated with a 6.16-point decrease (95% CI, 2.13-10.19 points). CONCLUSIONS: Our findings indicate that higher ECW/ICW ratios are associated with greater functional disability in patients with knee OA. Therefore, ECW/ICW ratio measurements with multi-frequency BIA can serve as valuable indicators for functional disability in patients with knee OA. Key Points • Higher extracellular-to-intracellular water (ECW/ICW) ratios are associated with greater functional disability levels in patients with knee osteoarthritis (OA). • ECW/ICW ratios are useful clinical signs as a biomarker for poor functional abilities in patients with knee OA. | en |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10067-021-05591-0 | en |
dc.rights | The full-text file will be made open to the public on 23 January 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | en |
dc.subject | Bioelectrical impedance analysis | en |
dc.subject | Extracellular-to-intracellular water ratio | en |
dc.subject | Functional disability | en |
dc.subject | Muscle quality | en |
dc.subject | Knee osteoarthritis | en |
dc.title | Extracellular-to-intracellular water ratios are associated with functional disability levels in patients with knee osteoarthritis: results from the Nagahama Study. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Clinical Rheumatology | en |
dc.identifier.volume | 40 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 2889 | - |
dc.identifier.epage | 2896 | - |
dc.relation.doi | 10.1007/s10067-021-05591-0 | - |
dc.textversion | author | - |
dc.identifier.pmid | 33486595 | - |
dcterms.accessRights | open access | - |
datacite.date.available | 2022-01-23 | - |
datacite.awardNumber | 25293141 | - |
datacite.awardNumber | 26670313 | - |
datacite.awardNumber | 26293198 | - |
datacite.awardNumber | 17H04182 | - |
datacite.awardNumber | 17H04126 | - |
datacite.awardNumber | 17H04123 | - |
datacite.awardNumber | 18K18450 | - |
datacite.awardNumber | 19K17634 | - |
datacite.awardNumber | 19K21493 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293141/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670313/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293198/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04182/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04126/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04123/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K18450/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17634/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K21493/ | - |
dc.identifier.pissn | 0770-3198 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 高齢者フレイルティの包括的疫学研究 | ja |
jpcoar.awardTitle | 家庭血圧計を用いた血圧日内変動測定の妥当性検証と予後予測能の検討 | ja |
jpcoar.awardTitle | 気道疾患の肺機能経年変化と全身病態に対する睡眠障害の影響と新治療体系の構築 | ja |
jpcoar.awardTitle | 気道疾患進行と睡眠障害合併時に対する統合的オミックス解析とバイオマーカーの探索 | ja |
jpcoar.awardTitle | 診察室外血圧の統合データベース構築と循環器リスクの比較評価 | ja |
jpcoar.awardTitle | フレイルと潜在性臓器障害との多重連関の理解深化のための学際的疫学研究 | ja |
jpcoar.awardTitle | 全人的コホート研究による認知症アトリスク高齢者を観取するための評価モデルの開発 | ja |
jpcoar.awardTitle | 閉塞性換気障害と動脈硬化進行に関与する新たなバイオマーカーの探索 | ja |
jpcoar.awardTitle | 変形性膝関節症患者の骨格筋変性に関連する因子の解明に向けた縦断研究 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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