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タイトル: | Non‐invasive Regulation of Cellular Morphology Using a Photoswitchable Mechanical DNA Polymer |
著者: | Sethi, Soumya Hidaka, Kumi Sugiyama, Hiroshi https://orcid.org/0000-0001-8923-5946 (unconfirmed) Endo, Masayuki |
著者名の別形: | 日高, 久美 杉山, 弘 遠藤, 政幸 |
キーワード: | cell morphology control DNA nanotechnology mechanical DNA polymers photoswitches |
発行日: | 6-Sep-2021 |
出版者: | Wiley |
誌名: | Angewandte Chemie International Edition |
巻: | 60 |
号: | 37 |
開始ページ: | 20342 |
終了ページ: | 20349 |
抄録: | The extracellular matrix (ECM) in which the cells reside provides a dynamic and reversible environment. Spatiotemporal cues are essential when cells are undergoing morphogenesis, repair and differentiation. Emulation of such an intricate system with reversible presentation of nanoscale cues can help us better understand cellular processes and can allow the precise manipulation of cell function in vitro. Herein, we formulated a photoswitchable DNA mechanical nanostructure containing azobenzene moieties and dynamically regulated the spatial distance between adhesion peptides using a photoswitchable DNA polymer with photoirradiation. We found that the DNA polymer reversibly forms two different structures, a relaxed linear and shrunken compact form, observed by AFM. Using the mechanical properties of this DNA polymer, UV and visible light irradiation induced a significant morphology change of the cells between a round shape and spindle shape, thus providing a tool to decipher the language of the ECM better. |
著作権等: | This is the peer reviewed version of the following article:[S. Sethi, K. Hidaka, H. Sugiyama, M. Endo, Angew. Chem. Int. Ed. 2021, 60, 20342.], which has been published in final form at https://doi.org/10.1002/anie.202105425. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. The full-text file will be made open to the public on 07 August 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/268793 |
DOI(出版社版): | 10.1002/anie.202105425 |
PubMed ID: | 33987972 |
出現コレクション: | 学術雑誌掲載論文等 |
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