Downloads: 179

Files in This Item:
File Description SizeFormat 
s00520-022-06822-z.pdf623.88 kBAdobe PDFView/Open
Title: Evaluation of indices for predicting recovery of exercise tolerance in patients surviving allogenic hematopoietic stem cell transplantation
Authors: Hamada, Ryota
Kondo, Tadakazu
Harada, Kazuhiro
Murao, Masanobu
Miyasaka, Junsuke
Yoshida, Michiko
Yonezawa, Honami
Nankaku, Manabu
Arai, Yasuyuki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-9662-5093 (unconfirmed)
Kanda, Junya  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-6704-3633 (unconfirmed)
Takaori-Kondo, Akifumi
Ikeguchi, Ryosuke  kyouindb  KAKEN_id
Matsuda, Shuichi  kyouindb  KAKEN_id
Author's alias: 濱田, 涼太
近藤, 忠一
村尾, 昌信
宮坂, 淳介
吉田, 路子
米澤, 穂波
南角, 学
新井, 康之
諫田, 淳也
髙折, 晃史
池口, 良輔
松田, 秀一
Keywords: Hematopoietic stem cell transplantation
6-min walk test
Knee extensor strength
Youden index
Issue Date: May-2022
Publisher: Springer Nature
Journal title: Supportive Care in Cancer
Volume: 30
Issue: 5
Start page: 4027
End page: 4034
Abstract: [Purpose] Decline in physical function in the early stage after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a major challenge. Exercise tolerance tests, such as the 6-min walk test, are useful markers for predicting exercise tolerance and various other traits, including cardiometabolic risk and non-relapse mortality. This retrospective cohort study aimed to investigate and identify predictors of recovery of exercise tolerance in the early stage after allo-HSCT. [Methods] Ninety-eight patients were classified into recovery and non-recovery groups according to the median 6-min walk distance (6MWD) at discharge. [Results] Logistic regression analysis revealed that pre-post change in knee extensor strength (ΔKES) and hematopoietic cell transplantation comorbidity index were useful predictors of recovery of exercise tolerance at discharge and moderate predictors of 6MWD recovery in the early post-transplant period. Receiver operating characteristic analysis showed that pre-transplant ΔKES was an accurate predictor of 6MWD recovery in the early post-transplant period. The cutoff point for ΔKES calculated using the Youden index was − 1.17 Nm/kg. [Conclusions] The results of this study emphasize the importance of the need for programs designed to prevent muscle weakness in the early period after allo-HSCT. The results from markers of recovery of exercise tolerance are promising and can be used for patient education in rehabilitation programs after allo-HSCT.
Rights: This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00520-022-06822-z
The full-text file will be made open to the public on 22 January 2023 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/268989
DOI(Published Version): 10.1007/s00520-022-06822-z
PubMed ID: 35066668
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.