Downloads: 179
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
s00520-022-06822-z.pdf | 623.88 kB | Adobe PDF | View/Open |
Title: | Evaluation of indices for predicting recovery of exercise tolerance in patients surviving allogenic hematopoietic stem cell transplantation |
Authors: | Hamada, Ryota Kondo, Tadakazu Harada, Kazuhiro Murao, Masanobu Miyasaka, Junsuke Yoshida, Michiko Yonezawa, Honami Nankaku, Manabu Arai, Yasuyuki https://orcid.org/0000-0002-9662-5093 (unconfirmed) Kanda, Junya https://orcid.org/0000-0002-6704-3633 (unconfirmed) Takaori-Kondo, Akifumi Ikeguchi, Ryosuke Matsuda, Shuichi |
Author's alias: | 濱田, 涼太 近藤, 忠一 村尾, 昌信 宮坂, 淳介 吉田, 路子 米澤, 穂波 南角, 学 新井, 康之 諫田, 淳也 髙折, 晃史 池口, 良輔 松田, 秀一 |
Keywords: | Hematopoietic stem cell transplantation 6-min walk test Knee extensor strength Youden index |
Issue Date: | May-2022 |
Publisher: | Springer Nature |
Journal title: | Supportive Care in Cancer |
Volume: | 30 |
Issue: | 5 |
Start page: | 4027 |
End page: | 4034 |
Abstract: | [Purpose] Decline in physical function in the early stage after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a major challenge. Exercise tolerance tests, such as the 6-min walk test, are useful markers for predicting exercise tolerance and various other traits, including cardiometabolic risk and non-relapse mortality. This retrospective cohort study aimed to investigate and identify predictors of recovery of exercise tolerance in the early stage after allo-HSCT. [Methods] Ninety-eight patients were classified into recovery and non-recovery groups according to the median 6-min walk distance (6MWD) at discharge. [Results] Logistic regression analysis revealed that pre-post change in knee extensor strength (ΔKES) and hematopoietic cell transplantation comorbidity index were useful predictors of recovery of exercise tolerance at discharge and moderate predictors of 6MWD recovery in the early post-transplant period. Receiver operating characteristic analysis showed that pre-transplant ΔKES was an accurate predictor of 6MWD recovery in the early post-transplant period. The cutoff point for ΔKES calculated using the Youden index was − 1.17 Nm/kg. [Conclusions] The results of this study emphasize the importance of the need for programs designed to prevent muscle weakness in the early period after allo-HSCT. The results from markers of recovery of exercise tolerance are promising and can be used for patient education in rehabilitation programs after allo-HSCT. |
Rights: | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00520-022-06822-z The full-text file will be made open to the public on 22 January 2023 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/268989 |
DOI(Published Version): | 10.1007/s00520-022-06822-z |
PubMed ID: | 35066668 |
Appears in Collections: | Journal Articles |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.