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タイトル: Long‐term clinical outcomes of external beam radiation therapy for oligometastatic prostate cancer: A combination of prostate‐targeted treatment and metastasis‐directed therapy
著者: Aizawa, Rihito  kyouindb  KAKEN_id
Takayama, Kenji
Nakamura, Kiyonao
Ogata, Takashi
Inoue, Takahiro
Yamasaki, Toshinari
Kobayashi, Takashi
Akamatsu, Shusuke
Tashiro, Yu
Ota, Hideto
Ogawa, Osamu
Mizowaki, Takashi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8135-8746 (unconfirmed)
著者名の別形: 相澤, 理人
高山, 賢二
中村, 清直
緒方, 隆司
井上, 貴博
山崎, 俊成
小林, 恭
赤松, 秀輔
田代, 結
太田, 秀人
小川, 修
溝脇, 尚志
キーワード: external beam radiation therapy
metastasis-directed therapy
oligometastasis
prostate cancer
prostate-targeted treatment
発行日: Jul-2021
出版者: Wiley
誌名: International Journal of Urology
巻: 28
号: 7
開始ページ: 749
終了ページ: 755
抄録: OBJECTIVE: To assess the efficacy of combination of prostate-targeted treatment and metastasis-directed therapy for oligometastatic prostate cancer. METHODS: We retrospectively evaluated the clinical outcomes of synchronously diagnosed oligometastatic prostate cancer patients treated with external beam radiation therapy for the prostate and all metastatic lesions (≤3 lesions) at Kyoto University Hospital between January 2004 and April 2019. The prescribed dose was basically ≥70 Gy for the prostate with or without whole pelvic irradiation, and ≥45 Gy for the metastatic lesions. Clinical outcomes were compared with a contemporary cohort of 55 synchronous oligometastatic prostate cancer patients treated with the standard of care. RESULTS: In total, 16 consecutive patients with synchronous oligometastatic prostate cancer were analyzed. The median follow-up period was 7.4 years. The 8-year overall survival, prostate cancer-specific survival, biochemical failure-free, clinical failure-free and castration-resistant prostate cancer-free rates were 64.8%, 71.3%, 38.5%, 47.3% and 67.3%, respectively. No grade 3 or higher radiation-induced late toxicities occurred. Patients with prostate-targeted treatment plus metastasis-directed therapy had a significantly higher castration-resistant prostate cancer-free rate than those without prostate-targeted treatment plus metastasis-directed therapy (P = 0.00741). CONCLUSIONS: Prostate-targeted treatment plus metastasis-directed therapy through external beam radiation therapy can result in favorable long-term disease-free and survival outcomes with acceptable morbidities among synchronous oligometastatic prostate cancer patients. Therefore, this approach may represent a promising treatment strategy for this population. Further investigation is required.
著作権等: This is the peer reviewed version of the following article: [Aizawa, R., Takayama, K., Nakamura, K., Ogata, T., Inoue, T., Yamasaki, T., Kobayashi, T., Akamatsu, S., Tashiro, Y., Ota, H., Ogawa, O. and Mizowaki, T. (2021), Long-term clinical outcomes of external beam radiation therapy for oligometastatic prostate cancer: A combination of prostate-targeted treatment and metastasis-directed therapy. Int. J. Urol., 28: 749-755.], which has been published in final form at https://doi.org/10.1111/iju.14567. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
The full-text file will be made open to the public on 02 April 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/269299
DOI(出版社版): 10.1111/iju.14567
PubMed ID: 33811409
出現コレクション:学術雑誌掲載論文等

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