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j.jphs.2021.04.006.pdf | 1.43 MB | Adobe PDF | 見る/開く |
タイトル: | MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations |
著者: | Tobori, Shota Hiyama, Haruka Miyake, Takahito https://orcid.org/0000-0002-4356-5883 (unconfirmed) Yano, Yuichi Nagayasu, Kazuki https://orcid.org/0000-0002-7438-732X (unconfirmed) Shirakawa, Hisashi https://orcid.org/0000-0002-4129-0978 (unconfirmed) Nakagawa, Takayuki https://orcid.org/0000-0003-1890-0843 (unconfirmed) Mori, Yasuo Kaneko, Shuji https://orcid.org/0000-0001-5152-5809 (unconfirmed) |
著者名の別形: | 戸堀, 翔太 緋山, 遥 三宅, 崇仁 矢野, 佑一 永安, 一樹 白川, 久志 中川, 貴之 金子, 周司 |
キーワード: | Sensory behavior Hairy skin MrgprB4 TRPA1 Trigeminal ganglion |
発行日: | Aug-2021 |
出版者: | Elsevier BV |
誌名: | Journal of Pharmacological Sciences |
巻: | 146 |
号: | 4 |
開始ページ: | 200 |
終了ページ: | 205 |
抄録: | Gentle touch such as stroking of the skin produces a pleasant feeling, which is detected by a rare subset of sensory neurons that express Mas-related G protein-coupled receptor B4 (MrgprB4) in mice. We examined small populations of MrgprB4-positive neurons in the trigeminal ganglion and the dorsal root ganglion, and most of these were sensitive to transient receptor potential ankyrin 1 (TRPA1) agonist but not TRPV1, TRPM8, or TRPV4 agonists. Deficiency of MrgprB4 did not affect noxious pain or itch behaviors in the hairless plantar and hairy cheek. Although behavior related to acetone-induced cold sensing in the hind paw was not changed, unpleasant sensory behaviors in response to acetone application or sucrose splash to the cheek were significantly enhanced in Mrgprb4-knockout mice as well as in TRPA1-knockout mice. These results suggest that MrgprB4 in the trigeminal neurons produces pleasant sensations in cooperation with TRPA1, rather than noxious or cold sensations. Pleasant sensations may modulate unpleasant sensations on the cheek via MrgprB4. |
著作権等: | © 2021 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license. |
URI: | http://hdl.handle.net/2433/274020 |
DOI(出版社版): | 10.1016/j.jphs.2021.04.006 |
PubMed ID: | 34116733 |
出現コレクション: | 学術雑誌掲載論文等 |
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