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dc.contributor.authorSano, Emien
dc.contributor.authorSuzuki, Tatsuyaen
dc.contributor.authorHashimoto, Rinaen
dc.contributor.authorItoh, Yumien
dc.contributor.authorSakamoto, Ayakaen
dc.contributor.authorSakai, Yusukeen
dc.contributor.authorSaito, Akatsukien
dc.contributor.authorOkuzaki, Daisukeen
dc.contributor.authorMotooka, Daisukeen
dc.contributor.authorMuramoto, Yukikoen
dc.contributor.authorNoda, Takeshien
dc.contributor.authorTakasaki, Tomohikoen
dc.contributor.authorSakuragi, Jun-Ichien
dc.contributor.authorMinami, Shoheien
dc.contributor.authorKobayashi, Takeshien
dc.contributor.authorYamamoto, Takuyaen
dc.contributor.authorMatsumura, Yasufumien
dc.contributor.authorNagao, Mikien
dc.contributor.authorOkamoto, Toruen
dc.contributor.authorTakayama, Kazuoen
dc.contributor.alternative佐野, 絵美ja
dc.contributor.alternative鈴木, 達也ja
dc.contributor.alternative橋本, 里菜ja
dc.contributor.alternative伊東, 祐美ja
dc.contributor.alternative坂本, 綾香ja
dc.contributor.alternative坂井, 祐介ja
dc.contributor.alternative齊藤, 暁ja
dc.contributor.alternative奥崎, 大介ja
dc.contributor.alternative元岡, 大祐ja
dc.contributor.alternative村本, 裕紀子ja
dc.contributor.alternative野田, 岳志ja
dc.contributor.alternative髙崎, 智彦ja
dc.contributor.alternative櫻木, 淳一ja
dc.contributor.alternative南, 昌平ja
dc.contributor.alternative小林, 剛ja
dc.contributor.alternative山本, 拓也ja
dc.contributor.alternative松村, 康史ja
dc.contributor.alternative長尾, 美紀ja
dc.contributor.alternative岡本, 徹ja
dc.contributor.alternative高山, 和雄ja
dc.date.accessioned2022-06-01T02:25:04Z-
dc.date.available2022-06-01T02:25:04Z-
dc.date.issued2022-
dc.identifier.urihttp://hdl.handle.net/2433/274182-
dc.description気管支オルガノイドを用いた新型コロナウイルス研究とその創薬応用. 京都大学プレスリリース. 2022-05-30.ja
dc.descriptionCOVID-19 Research Using Bronchial Organoids and Drug Discovery Applications. 京都大学プレスリリース. 2022-06-02.en
dc.description.abstractThe development of an in vitro cell model that can be used to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) research is expected. Here we conducted infection experiments in bronchial organoids (BO) and an BO-derived air-liquid interface model (BO-ALI) using 8 SARS-CoV-2 variants. The infection efficiency in BO-ALI was more than 1, 000 times higher than that in BO. Among the bronchial epithelial cells, we found that ciliated cells were infected with the virus, but basal cells were not. Ciliated cells died 7 days after the viral infection, but basal cells survived after the viral infection and differentiated into ciliated cells. Fibroblast growth factor 10 signaling was essential for this differentiation. These results indicate that BO and BO-ALI may be used not only to evaluate the cell response to SARS-CoV-2 and coronavirus disease 2019 (COVID-19) therapeutic agents, but also for airway regeneration studies.en
dc.language.isoeng-
dc.publisherSpringer Natureen
dc.rights© The Author(s) 2022en
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectRespiratory tract diseasesen
dc.subjectSARS-CoV-2en
dc.titleCell response analysis in SARS-CoV-2 infected bronchial organoidsen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleCommunications Biologyen
dc.identifier.volume5-
dc.relation.doi10.1038/s42003-022-03499-2-
dc.textversionpublisher-
dc.identifier.artnum516-
dc.addressCenter for iPS Cell Research and Application (CiRA), Kyoto Universityen
dc.addressInstitute for Advanced Co-Creation Studies, Research Institute for Microbial Diseases, Osaka Universityen
dc.addressCenter for iPS Cell Research and Application (CiRA), Kyoto Universityen
dc.addressInstitute for Advanced Co-Creation Studies, Research Institute for Microbial Diseases, Osaka Universityen
dc.addressCenter for iPS Cell Research and Application (CiRA), Kyoto Universityen
dc.addressLaboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi Universityen
dc.addressDepartment of Veterinary Science, Faculty of Agriculture, University of Miyazakien
dc.addressGenome Information Research Center, Research Institute for Microbial Diseases, Osaka University; Single Cell Genomics, Human Immunology, WPI Immunology Frontier Research Center, Osaka University; Institute for Open and Transdisciplinary Research Initiatives, Osaka Universityen
dc.addressGenome Information Research Center, Research Institute for Microbial Diseases, Osaka Universityen
dc.addressLaboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto Universityen
dc.addressLaboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto Universityen
dc.addressKanagawa Prefectural Institute of Public Healthen
dc.addressKanagawa Prefectural Institute of Public Healthen
dc.addressLaboratory of Viral Replication, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka Universityen
dc.addressLaboratory of Viral Replication, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka Universityen
dc.addressCenter for iPS Cell Research and Application (CiRA), Kyoto University; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University; Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP); AMED-CREST, Japan Agency for Medical Research and Development (AMED)en
dc.addressDepartment of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto Universityen
dc.addressDepartment of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto Universityen
dc.addressInstitute for Advanced Co-Creation Studies, Research Institute for Microbial Diseases, Osaka Universityen
dc.addressCenter for iPS Cell Research and Application (CiRA), Kyoto University; AMED-CREST, Japan Agency for Medical Research and Development (AMED)en
dc.identifier.pmid35637255-
dc.relation.urlhttps://www.cira.kyoto-u.ac.jp/j/pressrelease/news/220530-180000.html-
dc.relation.urlhttps://www.cira.kyoto-u.ac.jp/e/pressrelease/news/220602-170000.html-
dcterms.accessRightsopen access-
datacite.awardNumber21H03795-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H03795/-
dc.identifier.eissn2399-3642-
jpcoar.funderName日本学術振興会ja
jpcoar.awardTitle呼吸器疾患における基底細胞の役割解明ja
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