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タイトル: | Curdlan intake changes gut microbial composition, short-chain fatty acid production, and bile acid transformation in mice. |
著者: | K, Watanabe M, Yamano Y, Masujima R, Ohue-Kitano I*, Kimura |
著者名の別形: | 渡辺, 啓太 山野, 真由 増島, 侑紀 大植, 隆司 木村, 郁夫 |
キーワード: | Curdlan Short-chain fatty acids Gut microbiota Dietary fiber Bile acids |
発行日: | Sep-2021 |
出版者: | Elsevier BV |
誌名: | Biochemistry and Biophysics Reports |
巻: | 27 |
論文番号: | 101095 |
抄録: | Indigestible polysaccharides, such as dietary fibers, benefit the host by improving the intestinal environment. Short-chain fatty acids (SCFAs) produced by gut microbial fermentation from dietary fibers exert various physiological effects. The bacterial polysaccharide curdlan benefits the host intestinal environment, although its effect on energy metabolism and SCFA production remains unclear. Hence, this study aimed to elucidate the effect of curdlan intake on gut microbial profiles, SCFA production, and energy metabolism in a high-fat diet (HFD)-induced obese mouse model. Gut microbial composition of fecal samples from curdlan-supplemented HFD-fed mice indicated an elevated abundance of Bacteroidetes, whereas a reduced abundance of Firmicutes was noted at the phylum level compared with that in cellulose-supplemented HFD-fed mice. Moreover, curdlan supplementation resulted in an abundance of the family Bacteroidales S24-7 and Erysipelotrichaceae, and a reduction in Deferribacteres in the feces. Furthermore, curdlan supplementation elevated fecal SCFA levels, particularly butyrate. Although body weight and fat mass were not affected by curdlan supplementation in HFD-induced obese mice, HFD-induced hyperglycemia was significantly suppressed with an increase in plasma insulin and incretin GLP-1 levels. Curdlan supplementation elevated fecal bile acid and SCFA production, improved host metabolic functions by altering the gut microbial composition in mice. |
著作権等: | © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license. |
URI: | http://hdl.handle.net/2433/274207 |
DOI(出版社版): | 10.1016/j.bbrep.2021.101095 |
PubMed ID: | 34401531 |
出現コレクション: | 学術雑誌掲載論文等 |
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