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タイトル: | Continuum modeling for neuronal lamination during cerebral morphogenesis considering cell migration and tissue growth |
著者: | Takeda, Hironori Kameo, Yoshitaka Adachi, Taiji https://orcid.org/0000-0001-5280-4156 (unconfirmed) |
著者名の別形: | 竹田, 宏典 亀尾, 佳貴 安達, 泰治 |
キーワード: | continuum model tissue growth cell migration cerebral morphogenesis neuronal lamination |
発行日: | 2021 |
出版者: | Taylor & Francis Group |
誌名: | Computer Methods in Biomechanics and Biomedical Engineering |
巻: | 24 |
号: | 7 |
開始ページ: | 799 |
終了ページ: | 805 |
抄録: | For neuronal lamination during cerebral morphogenesis, later-born neurons must migrate through already-accumulated neurons. This neuronal migration is biochemically regulated by signaling molecules and mechanically affected by tissue deformation. To understand the neuronal lamination mechanisms, we constructed a continuum model of neuronal migration in a growing deformable tissue. We performed numerical analyses considering the migration promoted by signaling molecules and the tissue growth induced by neuron accumulation. The results suggest that the promoted migration and the space ensured by tissue growth are essential for neuronal lamination. The proposed model can describe the coupling of mechanical and biochemical mechanisms for neuronal lamination. |
著作権等: | This is an Accepted Manuscript of an article published by Taylor & Francis in 'Computer Methods in Biomechanics and Biomedica' on 2021, available online: http://www.tandfonline.com/10.1080/10255842.2020.1852554. The full-text file will be made open to the public on 08 December 2021 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/274740 |
DOI(出版社版): | 10.1080/10255842.2020.1852554 |
PubMed ID: | 33290089 |
出現コレクション: | 学術雑誌掲載論文等 |
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