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タイトル: | Development of an irradiation method for superficial tumours using a hydrogel bolus in an accelerator-based BNCT |
著者: | Sasaki, Akinori Tanaka, Hiroki Takata, Takushi Tamari, Yuki Watanabe, Tsubasa Hu, Naonori Kawabata, Shinji Kudo, Yoshihiro Mitsumoto, Toshinori Sakurai, Yoshinori Suzuki, Minoru https://orcid.org/0000-0002-5421-9417 (unconfirmed) |
著者名の別形: | 笹木, 彬礼 田中, 浩基 高田, 卓志 玉利, 勇樹 渡邉, 翼 呼, 尚徳 櫻井, 良憲 鈴木, 実 |
発行日: | Jan-2022 |
出版者: | IOP Publishing |
誌名: | Biomedical Physics & Engineering Express |
巻: | 8 |
号: | 1 |
論文番号: | 015015 |
抄録: | The aim of this study is the development of an irradiation method for the treatment of superficial tumours using a hydrogel bolus to produce thermal neutrons in accelerator-based Boron Neutron Capture Therapy (BNCT). To evaluate the neutron moderating ability of a hydrogel bolus, a water phantom with a hydrogel bolus was irradiated with an epithermal neutron beam from a cyclotron-based epithermal neutron source. Phantom simulating irradiation to the plantar position was manufactured using three-dimensional printing technology to perform an irradiation test of a hydrogel bolus. Thermal neutron fluxes on the surface of a phantom were evaluated and the results were compared with the Monte Carlo-based Simulation Environment for Radiotherapy Applications (SERA) treatment planning software. It was confirmed that a hydrogel bolus had the same neutron moderating ability as water, and the calculation results from SERA aligned with the measured values within approximately 5%. Furthermore, it was confirmed that the thermal neutron flux decreased at the edge of the irradiation field. It was possible to uniformly irradiate thermal neutrons by increasing the bolus thickness at the edge of the irradiation field, thereby successfully determining uniform dose distribution. An irradiation method for superficial tumours using a hydrogel bolus in the accelerator-based BNCT was established. |
著作権等: | © 2021 The Author(s). Published by IOP Publishing Ltd Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. |
URI: | http://hdl.handle.net/2433/274912 |
DOI(出版社版): | 10.1088/2057-1976/ac3d73 |
PubMed ID: | 34816337 |
出現コレクション: | 学術雑誌掲載論文等 |
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