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j.celrep.2021.109075.pdf | 11.81 MB | Adobe PDF | 見る/開く |
タイトル: | The embryonic ontogeny of the gonadal somatic cells in mice and monkeys |
著者: | Sasaki, Kotaro Oguchi, Akiko Cheng, Keren Murakawa, Yasuhiro ![]() ![]() ![]() Okamoto, Ikuhiro ![]() ![]() ![]() Ohta, Hiroshi ![]() ![]() Yabuta, Yukihiro Iwatani, Chizuru Tsuchiya, Hideaki Yamamoto, Takuya ![]() ![]() ![]() Seita, Yasunari Saitou, Mitinori |
著者名の別形: | 佐々木, 恒太郎 小口, 綾貴子 村川, 泰裕 岡本, 郁弘 大田, 浩 藪田, 幸宏 山本, 拓也 斎藤, 通紀 |
キーワード: | primate gonadogenesis monkey gonadogenesis single-cell transcriptomics intermediate mesoderm posterior intermediate mesoderm anterior-posterior regionalization genital ridge bipotential gonad adrenal gland hox genes |
発行日: | May-2021 |
出版者: | Elsevier BV |
誌名: | Cell Reports |
巻: | 35 |
号: | 5 |
論文番号: | 109075 |
抄録: | In the early fetal stage, the gonads are bipotent and only later become the ovary or testis, depending on the genetic sex. Despite many studies examining how sex determination occurs from biopotential gonads, the spatial and temporal organization of bipotential gonads and their progenitors is poorly understood. Here, using lineage tracing in mice, we find that the gonads originate from a T⁺ primitive streak through WT1⁺ posterior intermediate mesoderm and appear to share origins anteriorly with the adrenal glands and posteriorly with the metanephric mesenchyme. Comparative single-cell transcriptomic analyses in mouse and cynomolgus monkey embryos reveal the convergence of the lineage trajectory and genetic programs accompanying the specification of biopotential gonadal progenitor cells. This process involves sustained expression of epithelial genes and upregulation of mesenchymal genes, thereby conferring an epithelial-mesenchymal hybrid state. Our study provides key resources for understanding early gonadogenesis in mice and primates. |
著作権等: | © 2021 The Authors. This is an open access article under the Creative Commons Attribution 4.0 International license. |
URI: | http://hdl.handle.net/2433/275697 |
DOI(出版社版): | 10.1016/j.celrep.2021.109075 |
PubMed ID: | 33951437 |
出現コレクション: | 学術雑誌掲載論文等 |
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