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cpb.c22-00042.pdf | 4.12 MB | Adobe PDF | 見る/開く |
タイトル: | Regulatory Roles of N- and C-Terminal Cytoplasmic Regions of P4-ATPases |
著者: | Shin, Hye-Won https://orcid.org/0000-0002-9138-9554 (unconfirmed) Takatsu, Hiroyuki |
著者名の別形: | 申, 惠媛 髙津, 宏之 |
キーワード: | lipid bilayer lipid asymmetry P4-ATPase flippase |
発行日: | 1-Aug-2022 |
出版者: | Pharmaceutical Society of Japan |
誌名: | Chemical and Pharmaceutical Bulletin |
巻: | 70 |
号: | 8 |
開始ページ: | 524 |
終了ページ: | 532 |
抄録: | P4-ATPases, which are subfamily members of P-type ATPase superfamily, translocate membrane lipids from the exoplasmic/luminal leaflet to the cytoplasmic leaflet, thus regulating trans-bilayer lipid asymmetry. Mammalian P4-ATPases localize to the specific subcellular organelles or the plasma membrane where they translocate the specific lipids. Although recent advances in the structural analysis of P4-ATPases have improved our understanding of lipid transporting machinery, the mechanism of substrate specificity and the regulatory mechanism of the enzymes remain largely unknown. Recent studies have uncovered several specific localization and regulatory mechanisms of P4-ATPases. Here, we review the current understanding of the regulatory mechanism of P4-ATPase activity and localization in mammalian cells. |
著作権等: | © 2022 The Pharmaceutical Society of Japan |
URI: | http://hdl.handle.net/2433/275866 |
DOI(出版社版): | 10.1248/cpb.c22-00042 |
PubMed ID: | 35908917 |
出現コレクション: | 学術雑誌掲載論文等 |
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