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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| cbic.202100533.pdf | 763.96 kB | Adobe PDF | 見る/開く |
| タイトル: | Strong and Specific Recognition of CAG/CTG Repeat DNA (5'-dWGCWGCW-3') by a Cyclic Pyrrole-Imidazole Polyamide |
| 著者: | Hirose, Yuki Ohno, Tomo Asamitsu, Sefan Hashiya, Kaori Bando, Toshikazu  Sugiyama, Hiroshi   https://orcid.org/0000-0001-8923-5946 (unconfirmed) |
| 著者名の別形: | 廣瀬, 優希 大野, 智 朝光, 世煌 橋谷, かおり 板東, 俊和 杉山, 弘 |
| キーワード: | CAG/CTG repeats DNA recognition pyrrole-imidazole polyamides triplet repeats |
| 発行日: | 19-Jan-2022 |
| 出版者: | Wiley |
| 誌名: | ChemBioChem |
| 巻: | 23 |
| 号: | 2 |
| 論文番号: | e202100533 |
| 抄録: | Abnormally expanded CAG/CTG repeat DNA sequences lead to a variety of neurological diseases, such as Huntington's disease. Here, we synthesized a cyclic pyrrole-imidazole polyamide (cPIP), which can bind to the minor groove of the CAG/CTG DNA sequence. The double-stranded DNA melting temperature (Tm ) and surface plasmon resonance assays revealed the high binding affinity of the cPIP. In addition, next-generation sequencing showed that the cPIP had high specificity for its target DNA sequence. |
| 著作権等: | © 2021 The Authors. ChemBioChem published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| URI: | http://hdl.handle.net/2433/276072 |
| DOI(出版社版): | 10.1002/cbic.202100533 |
| PubMed ID: | 34796607 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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