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dc.contributor.authorWashizaki, Ayakaen
dc.contributor.authorMurayama, Asakoen
dc.contributor.authorMurata, Megumien
dc.contributor.authorKiyohara, Tomokoen
dc.contributor.authorYato, Keigoen
dc.contributor.authorYamada, Norieen
dc.contributor.authorAly, Hussein Hassanen
dc.contributor.authorTanaka, Tomohisaen
dc.contributor.authorMoriishi, Kohjien
dc.contributor.authorNishitsuji, Hironorien
dc.contributor.authorShimotohno, Kunitadaen
dc.contributor.authorGoh, Yasumasaen
dc.contributor.authorIshii, Ken J.en
dc.contributor.authorYotsuyanagi, Hiroshien
dc.contributor.authorMuramatsu, Masamichien
dc.contributor.authorIshii, Kojien
dc.contributor.authorTakahashi, Yoshimasaen
dc.contributor.authorSuzuki, Ryosukeen
dc.contributor.authorAkari, Hirofumien
dc.contributor.authorKato, Takanobuen
dc.contributor.alternative鷲崎, 彩夏ja
dc.contributor.alternative村山, 麻子ja
dc.contributor.alternative村田, めぐみja
dc.contributor.alternative清原, 知子ja
dc.contributor.alternative矢藤, 慶悟ja
dc.contributor.alternative山田, 典栄ja
dc.contributor.alternativeアリ, フセインja
dc.contributor.alternative田中, 智久ja
dc.contributor.alternative森石, 恆司ja
dc.contributor.alternative西辻, 裕紀ja
dc.contributor.alternative下遠野, 邦忠ja
dc.contributor.alternative郷, 保正ja
dc.contributor.alternative石井, 健ja
dc.contributor.alternative四柳, 宏ja
dc.contributor.alternative村松, 正道ja
dc.contributor.alternative石井, 孝司ja
dc.contributor.alternative高橋, 宜聖ja
dc.contributor.alternative鈴木, 亮介ja
dc.contributor.alternative明里, 宏文ja
dc.contributor.alternative加藤, 孝宣ja
dc.date.accessioned2022-09-08T04:41:54Z-
dc.date.available2022-09-08T04:41:54Z-
dc.date.issued2022-
dc.identifier.urihttp://hdl.handle.net/2433/276204-
dc.description優れたB型肝炎予防ワクチン開発に成功 --既存ワクチンの弱点克服へ--. 京都大学プレスリリース. 2022-09-07.ja
dc.description.abstractAlthough the current hepatitis B (HB) vaccine comprising small-HBs antigen (Ag) is potent and safe, attenuated prophylaxis against hepatitis B virus (HBV) with vaccine-escape mutations (VEMs) has been reported. We investigate an HB vaccine consisting of large-HBsAg that overcomes the shortcomings of the current HB vaccine. Yeast-derived large-HBsAg is immunized into rhesus macaques, and the neutralizing activities of the induced antibodies are compared with those of the current HB vaccine. Although the antibodies induced by the current HB vaccine cannot prevent HBV infection with VEMs, the large-HBsAg vaccine-induced antibodies neutralize those infections. The HBV genotypes that exhibited attenuated neutralization via these vaccines are different. Here, we show that the HB vaccine consisting of large-HBsAg is useful to compensate for the shortcomings of the current HB vaccine. The combined use of these HB vaccines may induce antibodies that can neutralize HBV strains with VEMs or multiple HBV genotypes.en
dc.language.isoeng-
dc.publisherSpringer Natureen
dc.rights© The Author(s) 2022en
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectHepatitis Ben
dc.subjectHepatitis B virusen
dc.subjectInfectionen
dc.subjectVaccinesen
dc.subjectViral hepatitisen
dc.titleNeutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigenen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleNature Communicationsen
dc.identifier.volume13-
dc.relation.doi10.1038/s41467-022-32910-z-
dc.textversionpublisher-
dc.identifier.artnum5207-
dc.addressCenter for the Evolutionary Origins of Human Behavior, Kyoto Universityen
dc.addressDepartment of Virology II, National Institute of Infectious Diseasesen
dc.addressCenter for the Evolutionary Origins of Human Behavior, Kyoto Universityen
dc.addressDepartment of Virology II, National Institute of Infectious Diseasesen
dc.addressDepartment of Virology II, National Institute of Infectious Diseasesen
dc.addressDepartment of Virology II, National Institute of Infectious Diseasesen
dc.addressDepartment of Virology II, National Institute of Infectious Diseasesen
dc.addressDepartment of Microbiology, Graduate School of Medicine, University of Yamanashien
dc.addressDepartment of Microbiology, Graduate School of Medicine, University of Yamanashi; Division of Hepatitis Virology, Institute for Genetic Medicine, Hokkaido Universityen
dc.addressDepartment of Virology and Parasitology, Fujita Health University School of Medicineen
dc.addressGenome Medical Sciences Project, National Center for Global Health and Medicineen
dc.addressResearch Laboratory, Beacle, Inc.en
dc.addressDivision of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyoen
dc.addressDivision of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyoen
dc.addressDepartment of Virology II, National Institute of Infectious Diseasesen
dc.addressDepartment of Quality Assurance, Radiation Safety, and Information System, National Institute of Infectious Diseasesen
dc.addressResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseasesen
dc.addressDepartment of Virology II, National Institute of Infectious Diseasesen
dc.addressCenter for the Evolutionary Origins of Human Behavior, Kyoto Universityen
dc.addressDepartment of Virology II, National Institute of Infectious Diseasesen
dc.identifier.pmid36064848-
dc.relation.urlhttps://www.kyoto-u.ac.jp/ja/research-news/2022-09-07-3-
dcterms.accessRightsopen access-
dc.identifier.eissn2041-1723-
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