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タイトル: | Early social rearing, the V1A arginine vasopressin receptor genotype, and autistic traits in chimpanzees |
著者: | Weiss, Alexander Wilson, Vanessa A. D. Hopkins, William D. |
キーワード: | autism AVPR1A development mother primate vasopressin |
発行日: | Sep-2021 |
出版者: | International Society for Autism Research Wiley |
誌名: | Autism Research |
巻: | 14 |
号: | 9 |
開始ページ: | 1843 |
終了ページ: | 1853 |
抄録: | Previous studies found associations between autism-related phenotypes and both rearing and V1A arginine vasopressin receptor (AVPR1A) genotypes. We tested whether these exposures as well as their interaction were associated with autism-related phenotypes in 121 laboratory-housed chimpanzees. We used expert-derived weights to obtain autism scores from ratings on the 43-item Chimpanzee Personality Questionnaire; higher scores indicated more autistic-like traits. The first model included fixed effects for sex, age, and rearing, and a random effect that addressed the relatedness of subjects. The second model was the same except that it also included the rearing × AVPR1A genotype interaction as a fixed effect. Both models indicated that the phenotype was moderately heritable and that chimpanzees reared by their mothers had lower scores on the scale. The effect of genotype in both models indicated that chimpanzees with an indel deletion had higher scores on the scale, although the credible interval included zero. Moreover, the rearing × genotype interaction in the second model indicated that chimpanzees who possessed the non-deletion genotype and who were reared by their mother were at even greater risk. The credible interval for this effect did not include zero, but fit statistics indicated that the model without the interaction was marginally better, and the interaction was in the opposite direction than we expected based on previous work. These findings highlight the importance of rearing effects in the typical social development of our closet-living nonhuman relative. |
著作権等: | © 2021 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/276541 |
DOI(出版社版): | 10.1002/aur.2550 |
PubMed ID: | 34089305 |
出現コレクション: | 学術雑誌掲載論文等 |
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