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タイトル: | A comparison of the usefulness of nuclear beta‐catenin in the diagnosis of desmoid‐type fibromatosis among commonly used anti‐beta‐catenin antibodies |
著者: | Yamada, Yosuke ![]() ![]() Hirata, Masahiro Sakamoto, Akio ![]() ![]() Noguchi, Takashi Ito, Kan Nishida, Yoshihiro Matsuda, Shuichi ![]() ![]() Haga, Hironori ![]() ![]() |
著者名の別形: | 山田, 洋介 平田, 勝啓 坂本, 昭夫 野口, 貴志 松田, 秀一 羽賀, 博典 |
キーワード: | beta-catenin beta-catenin 1 CTNNB1 cytoplasm desmoid-type fibromatosis DNA mutational analysis immunohistochemistry 17C2 14 LEF1 |
発行日: | Jun-2021 |
出版者: | Wiley |
誌名: | Pathology International |
巻: | 71 |
号: | 6 |
開始ページ: | 392 |
終了ページ: | 399 |
抄録: | Desmoid-type fibromatosis (DF) is a locally aggressive but non-metastatic (myo)fibroblastic neoplasm. A hallmark of the tumor is nuclear positivity for beta-catenin in immunohistochemistry due mostly to CTNNB1 mutations. However, a recent study has reported that even beta-catenin ‘nuclear-negative’ DFs can harbor CTNNB1 mutations and that the positive ratio of nuclear beta-catenin in DF is different among antibodies. Here, we reviewed soft tissue lesions for which the possibility of DF was considered and compared the sensitivity and specificity of nuclear beta-catenin for the diagnosis of DF among commonly used anti-beta-catenin antibodies, i.e., clone beta-catenin 1, 17C2 and 14. We analyzed 26 cases of DF, 28 cases of benign fibroblastic lesions, and 27 cases of other soft tissue tumors. The sensitivity and specificity of nuclear beta-catenin for the diagnosis of DF were different among antibodies; 54% and 98% in clone beta-catenin 1, 85% and 84% in 17C2, and 96% and 62% in 14. IHC of LEF1 showed comparable results with IHC of beta-catenin, with a sensitivity of 88% and specificity of 76%. Additionally, when beta-catenin 1 was used, DFs showed characteristic dotted cytoplasmic staining, often appearing as rings. Our results might be helpful for making a correct diagnosis of DF. |
著作権等: | This is the peer reviewed version of the following article: ['Pathology International', Volume71, Issue6, June 2021, Pages 392-399], which has been published in final form at https://doi.org/10.1111/pin.13096. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. The full-text file will be made open to the public on 31 March 2022 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/276590 |
DOI(出版社版): | 10.1111/pin.13096 |
PubMed ID: | 33788979 |
出現コレクション: | 学術雑誌掲載論文等 |
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