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j.bbrep.2021.101127.pdf | 3.51 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Ng, Su-Ping | en |
dc.contributor.author | Nomura, Wataru | en |
dc.contributor.author | Takahashi, Haruya | en |
dc.contributor.author | Inoue, Kazuo | en |
dc.contributor.author | Kawada, Teruo | en |
dc.contributor.author | Goto, Tsuyoshi | en |
dc.contributor.alternative | 黄, 淑萍 | ja |
dc.contributor.alternative | 野村, 亘 | ja |
dc.contributor.alternative | 高橋, 春弥 | ja |
dc.contributor.alternative | 井上, 和生 | ja |
dc.contributor.alternative | 河田, 照雄 | ja |
dc.contributor.alternative | 後藤, 剛 | ja |
dc.date.accessioned | 2022-10-18T05:17:38Z | - |
dc.date.available | 2022-10-18T05:17:38Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.uri | http://hdl.handle.net/2433/276775 | - |
dc.description.abstract | Methylglyoxal (MG) is a metabolite derived from glycolysis whose levels in the blood and tissues of patients with diabetes are higher than those of healthy individuals, suggesting that MG is associated with the development of diabetic complications. However, it remains unknown whether high levels of MG are a cause or consequence of diabetes. Here, we show that MG negatively affects the expression of uncoupling protein 1 (UCP1), which is involved in thermogenesis and the regulation of systemic metabolism. Decreased Ucp1 expression is associated with obesity and type 2 diabetes. We found that MG attenuated the increase in Ucp1 expression following treatment with isoproterenol in beige adipocytes. However, MG did not affect protein kinase A signaling, the core coordinator of isoproterenol-induced Ucp1 expression. Instead, MG activated c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases. We found that JNK inhibition, but not p38, recovered isoproterenol-stimulated Ucp1 expression under MG treatment. Altogether, these results suggest an inhibitory role of MG on the thermogenic function of beige adipocytes through the JNK signaling pathway. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2021 The Authors. Published by Elsevier B.V. | en |
dc.rights | This is an open access article under the CC BY license. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Methylglyoxal | en |
dc.subject | Beige adipocytes | en |
dc.subject | Ucp1 | en |
dc.subject | JNK | en |
dc.title | Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Biochemistry and Biophysics Reports | en |
dc.identifier.volume | 28 | - |
dc.relation.doi | 10.1016/j.bbrep.2021.101127 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 101127 | - |
dc.identifier.pmid | 34527816 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 19K05949 | - |
datacite.awardNumber | 20K21755 | - |
datacite.awardNumber | 20J23198 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K05949/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21755/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20J23198/ | - |
dc.identifier.eissn | 2405-5808 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | TORC2シグナルの活性化に寄与する細胞膜脂質の作用機序の解析 | ja |
jpcoar.awardTitle | 褐色脂肪組織による骨格筋機能制御機構の解明 新規褐色脂肪欠失マウスを用いた検討 | ja |
jpcoar.awardTitle | 解糖系代謝物の脂肪細胞における新規な役割:脂質代謝を制御するシグナル分子 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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