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タイトル: Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in 40–69-years subjects
著者: Ohashi, Shinya  kyouindb  KAKEN_id
Maruno, Takahisa  kyouindb  KAKEN_id
Fukuyama, Keita  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-8176-6961 (unconfirmed)
Kikuchi, Osamu  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-5012-5897 (unconfirmed)
Sunami, Tomohiko
Kondo, Yuki
Imai, Seiichiro
Matsushima, Aki  kyouindb  KAKEN_id
Suzuki, Kazuyo
Usui, Fumika
Yakami, Masahiro  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8487-405X (unconfirmed)
Yamada, Atsushi  kyouindb  KAKEN_id
Isoda, Hiroyoshi  KAKEN_id
Matsumoto, Shigemi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-6453-7489 (unconfirmed)
Seno, Hiroshi  kyouindb  KAKEN_id
Muto, Manabu  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-3127-8203 (unconfirmed)
Inoue, Mayumi  kyouindb  KAKEN_id
著者名の別形: 大橋, 真也
丸野, 貴久
福山, 啓太
菊池, 理
角南, 智彦
近藤, 雄紀
今井, 誠一郎
松島, 晶
鈴木, 和代
八上, 全弘
山田, 敦
磯田, 裕義
松本, 繁巳
妹尾, 浩
武藤, 学
井上, 真由美
キーワード: Reflux erosive esophagitis
Visceral fat obesity
Visceral fat area
Abdominal computed tomography
発行日: Oct-2021
出版者: Springer Nature
誌名: Esophagus
巻: 18
号: 4
開始ページ: 889
終了ページ: 899
抄録: [Background] Visceral fat obesity can be defined quantitatively by abdominal computed tomography, however, the usefulness of measuring visceral fat area to assess the etiology of gastrointestinal reflux disease has not been fully elucidated. [Methods] A total of 433 healthy subjects aged 40–69 years (234 men, 199 women) were included in the study. The relationship between obesity-related factors (total fat area, visceral fat area, subcutaneous fat area, waist circumference, and body mass index) and the incidence of reflux erosive esophagitis was investigated. Lifestyle factors and stomach conditions relevant to the onset of erosive esophagitis were also analyzed. [Results] The prevalence of reflux erosive esophagitis was 27.2% (118/433; 106 men, 12 women). Visceral fat area was higher in subjects with erosive esophagitis than in those without (116.6 cm2 vs. 64.9 cm2, respectively). The incidence of erosive esophagitis was higher in subjects with visceral fat obesity (visceral fat area ≥ 100 cm2) than in those without (61.2% vs. 12.8%, respectively). Visceral fat obesity had the highest odds ratio (OR) among obesity-related factors. Multivariate analysis showed that visceral fat area was associated with the incidence of erosive esophagitis (OR = 2.18), indicating that it is an independent risk factor for erosive esophagitis. In addition, daily alcohol intake (OR = 1.54), gastric atrophy open type (OR = 0.29), and never-smoking history (OR = 0.49) were also independently associated with the development of erosive esophagitis. [Conclusions] Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in subjects aged 40–69 years.
著作権等: © The Author(s) 2021
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
URI: http://hdl.handle.net/2433/276960
DOI(出版社版): 10.1007/s10388-021-00859-5
PubMed ID: 34117973
出現コレクション:学術雑誌掲載論文等

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