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| Title: | Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant |
| Authors: | Saito, Akatsuki Tamura, Tomokazu Zahradnik, Jiri Deguchi, Sayaka Tabata, Koshiro Anraku, Yuki Kimura, Izumi Ito, Jumpei Yamasoba, Daichi Nasser, Hesham Toyoda, Mako Nagata, Kayoko Uriu, Keiya Kosugi, Yusuke Fujita, Shigeru Shofa, Maya Monira Begum, M.S.T. Shimizu, Ryo Oda, Yoshitaka Suzuki, Rigel Ito, Hayato Nao, Naganori Wang, Lei Tsuda, Masumi Yoshimatsu, Kumiko Kuramochi, Jin Kita, Shunsuke Sasaki-Tabata, Kaori Fukuhara, Hideo Maenaka, Katsumi Yamamoto, Yuki Nagamoto, Tetsuharu Asakura, Hiroyuki Nagashima, Mami Sadamasu, Kenji Yoshimura, Kazuhisa Ueno, Takamasa Schreiber, Gideon Takaori-Kondo, Akifumi The Genotype to Phenotype Japan (G2P-Japan) Consortium Shirakawa, Kotaro    https://orcid.org/0000-0002-7469-1276 (unconfirmed)Sawa, Hirofumi Irie, Takashi Hashiguchi, Takao https://orcid.org/0000-0001-7578-7571 (unconfirmed)Takayama, Kazuo https://orcid.org/0000-0002-1132-2457 (unconfirmed)Matsuno, Keita Tanaka, Shinya Ikeda, Terumasa Fukuhara, Takasuke Sato, Kei |
| Author's alias: | 齊藤, 暁 田村, 友和 出口, 清香 田畑, 耕史郎 安楽, 佑樹 木村, 出海 伊東, 潤平 山岨, 大智 豊田, 真子 永田, 佳代子 瓜生, 慧也 小杉, 優介 藤田, 滋 清水, 凌 小田, 義崇 鈴木, 理滋 伊藤, 駿 直, 亨則 王, 磊 津田, 真寿美 吉松, 組子 倉持, 仁 喜多, 俊介 田畑, 香織 福原, 秀雄 前仲, 勝実 山本, 佑樹 永元, 哲治 浅倉, 弘幸 長島, 真美 貞升, 健志 吉村, 和久 上野, 貴将 高折, 晃史 白川, 康太郎 澤, 洋文 入江, 崇 橋口, 隆生 高山, 和雄 松野, 啓太 田中, 伸哉 池田, 輝政 福原, 崇介 佐藤, 佳 |
| Keywords: | SARS-CoV-2 COVID-19 Omicron BA.2.75 transmissibility immune resistance antiviral drug resistance pathogenicity |
| Issue Date: | 9-Nov-2022 |
| Publisher: | Elsevier BV Cell Press |
| Journal title: | Cell Host and Microbe |
| Volume: | 30 |
| Issue: | 11 |
| Start page: | 1540 |
| End page: | 1555 |
| Thesis number: | e15 |
| Abstract: | The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5. |
| Description: | SARS-CoV-2オミクロンBA.2.75株（通称ケンタウロス）のウイルス学的性状の解明. 京都大学プレスリリース. 2022-10-12. |
| Rights: | © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the Creative Commons Attribution 4.0 International license. |
| URI: | http://hdl.handle.net/2433/277087 |
| DOI(Published Version): | 10.1016/j.chom.2022.10.003 |
| PubMed ID: | 36272413 |
| Related Link: | https://www.kyoto-u.ac.jp/ja/research-news/2022-10-12-3 |
| Appears in Collections: | Journal Articles |
This item is licensed under a Creative Commons License
