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タイトル: Patient-reported dyspnea and health predict waitlist mortality in patients waiting for lung transplantation in Japan
著者: Ikeda, Masaki
Oga, Toru
Chen-Yoshikawa, Toyofumi F.
Tokuno, Junko
Oto, Takahiro
Okawa, Tomoyo
Okada, Yoshinori
Akiba, Miki
Tanaka, Satona  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-0789-2350 (unconfirmed)
Yamada, Yoshito  KAKEN_id  orcid https://orcid.org/0000-0002-7659-8067 (unconfirmed)
Yutaka, Yojiro
Ohsumi, Akihiro
Nakajima, Daisuke
Hamaji, Masatsugu
Isomi, Maki
Chin, Kazuo
Date, Hiroshi  KAKEN_id
著者名の別形: 池田, 政樹
徳野, 純子
田中, 里奈
山田, 義人
豊, 洋次郎
大角, 明宏
中島, 大輔
濱路, 政嗣
陳, 和夫
伊達, 洋至
キーワード: Lung transplantation
Waitlist mortality
Health-related quality of life
Modifed Medical Research Council dyspnea scale
St. George’s Respiratory Questionnaire
発行日: 21-Apr-2021
出版者: Springer Nature
誌名: Respiratory Research
巻: 22
論文番号: 116
抄録: Background: Waitlist mortality due to donor shortage for lung transplantation is a serious problem worldwide. Currently, the selection of recipients in Japan is mainly based on the registration order. Hence, scientific evidence for risk stratification regarding waitlist mortality is urgently needed. We hypothesized that patient-reported dyspnea and health would predict mortality in patients waitlisted for lung transplantation. Methods: We analyzed factors related to waitlist mortality using data of 203 patients who were registered as candidates for lung transplantation from deceased donors. Dyspnea was evaluated using the modified Medical Research Council (mMRC) dyspnea scale, and the health status was determined with St. George's Respiratory Questionnaire (SGRQ). Results: Among 197 patients who met the inclusion criteria, the main underlying disease was interstitial lung disease (99 patients). During the median follow-up period of 572 days, 72 patients died and 96 received lung transplantation (69 from deceased donors). Univariable competing risk analyses revealed that both mMRC dyspnea and SGRQ Total score were significantly associated with waitlist mortality (p = 0.003 and p < 0.001, respectively) as well as age, interstitial lung disease, arterial partial pressure of carbon dioxide, and forced vital capacity. Multivariable competing risk analyses revealed that the mMRC and SGRQ score were associated with waitlist mortality in addition to age and interstitial lung disease. Conclusions: Both mMRC dyspnea and SGRQ score were significantly associated with waitlist mortality, in addition to other clinical variables such as patients' background, underlying disease, and pulmonary function. Patient-reported dyspnea and health may be measured through multi-dimensional analysis (including subjective perceptions) and for risk stratification regarding waitlist mortality.
著作権等: © The Author(s) 2021.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
URI: http://hdl.handle.net/2433/277449
DOI(出版社版): 10.1186/s12931-021-01715-x
PubMed ID: 33882928
出現コレクション:学術雑誌掲載論文等

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