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タイトル: | Detection Sensitivity of Retinitis Pigmentosa Progression Using Static Perimetry and Optical Coherence Tomography |
著者: | Hasegawa, Tomoko Oishi, Akio Ikeda, Hanako Ohashi Numa, Shogo Miyata, Manabu https://orcid.org/0000-0002-7574-1749 (unconfirmed) Otsuka, Yuki Oishi, Maho Tsujikawa, Akitaka |
著者名の別形: | 長谷川, 智子 大石, 明生 池田, 華子 沼, 尚吾 宮田, 学 大塚, 悠生 大石, 真秀 辻川, 明孝 |
キーワード: | retinitis pigmentosa optical coherence tomography ellipsoid zone automated perimetry disease progression |
発行日: | Jul-2021 |
出版者: | Association for Research in Vision and Ophthalmology (ARVO) |
誌名: | Translational Vision Science & Technology |
巻: | 10 |
号: | 8 |
論文番号: | 31 |
抄録: | Purpose: To compare the detection sensitivities of the progression of retinitis pigmentosa (RP) by automated perimetry to obtain the mean deviation (MD) and total point score and by optical coherence tomography (OCT) to determine the residual ellipsoid zone (EZ) length and thickness of retinal layers. Methods: Twenty-two eyes of 22 patients with RP who underwent annual automated perimetry (Humphrey Field Analyzer 10-2) and OCT examinations during the same period more than four times were included. Disease progression was evaluated using linear regression analysis with the least-squares method. The disease progression speed and interinspection fluctuations for the different examinations were compared using standardized values. The progression detection ability factor, defined as the average of the least squares divided by the square of annual change, was used to compare the sensitivities of the examinations for detecting the progression of RP. Results: EZ length showed a high correlation with MD (R = 0.87; P = 1.12E-07) at baseline. Disease progression was detected more frequently using EZ length (12/22 eyes) than using MD (3/22 eyes; P = 0.004) or central retinal thickness (1/11 eyes; P = 0.012). Linear regression using standardized values showed that the EZ length had the fastest annual change, with the smallest least absolute values. EZ length was more sensitive for detecting RP progression than MD, total point score, visual acuity, or central retinal thickness. Conclusions: EZ measurement was sensitive for detecting RP progression, and the results of this study indicate that EZ length is appropriate for end points in clinical trials. Translational Relevance: The study provides a basis for conducting future clinical trials. |
著作権等: | Copyright 2021 The Authors This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
URI: | http://hdl.handle.net/2433/277458 |
DOI(出版社版): | 10.1167/tvst.10.8.31 |
PubMed ID: | 34323953 |
出現コレクション: | 学術雑誌掲載論文等 |
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