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dc.contributor.author | Sasase, Tomohiko | en |
dc.contributor.author | Fatchiyah, Fatchiyah | en |
dc.contributor.author | Ohta, Takeshi | en |
dc.contributor.alternative | 笹瀬, 智彦 | ja |
dc.contributor.alternative | 太田, 毅 | ja |
dc.date.accessioned | 2022-11-24T05:17:53Z | - |
dc.date.available | 2022-11-24T05:17:53Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://hdl.handle.net/2433/277464 | - |
dc.description.abstract | Transient receptor potential vanilloid (TRPV) channels are TRP homologs and have been classified into six subfamilies. They are unique mediators of sensory signals with multiple physiological effects and are potential targets for developing new therapies targeting human diseases. TRPV channels play crucial roles in normal physiological processes, and their dysfunction has been implicated in various disease states. Several small-molecule compounds, such as TRPV1 and TRPV3 antagonists, have been developed as novel analgesic agents. A better understanding of the physiological functions of TRPV channels would lead to progress in life science. In this review, we focus on various functions of TRPV channels, including pain sensing, temperature sensing, and metabolic control, as well as summarize the basal properties and pathophysiological contributions of six TRPV channels. Moreover, we discuss the pharmacological effects of endogenous and exogenous ligands on TRPV channels and related diseases. | en |
dc.language.iso | eng | - |
dc.publisher | AEPress, s.r.o. | en |
dc.rights | © The Authors 2022. | en |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial 4.0 International License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.subject | TRPV channels | en |
dc.subject | Sensory system | en |
dc.subject | Channel diseases | en |
dc.subject | Drug discovery | en |
dc.title | Transient Receptor Potential Vanilloid (TRPV) channels: Basal Properties and physiological potential | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | General physiology and biophysics | en |
dc.identifier.volume | 41 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 165 | - |
dc.identifier.epage | 190 | - |
dc.relation.doi | 10.4149/gpb_2022016 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 35615999 | - |
dcterms.accessRights | open access | - |
dc.identifier.eissn | 1338-4325 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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