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dc.contributor.author | Kitao, Koichi | en |
dc.contributor.author | Miyazawa, Takayuki | en |
dc.contributor.author | Nakagawa, So | en |
dc.contributor.alternative | 北尾, 晃一 | ja |
dc.contributor.alternative | 宮沢, 孝幸 | ja |
dc.contributor.alternative | 中川, 草 | ja |
dc.date.accessioned | 2022-11-24T07:08:06Z | - |
dc.date.available | 2022-11-24T07:08:06Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://hdl.handle.net/2433/277471 | - |
dc.description.abstract | Endogenous retroviruses (ERVs) have played an essential role in the evolution of mammals. ERV-derived genes are reported in the therians, many of which are involved in placental development; however, the contribution of the ERV-derived genes in monotremes, which are oviparous mammals, remains to be uncovered. Here, we conducted a comprehensive search for possible ERV-derived genes in platypus and echidna genomes and identified three reverse transcriptase-like genes named RTOM1, RTOM2, and RTOM3 clustered in the GRIP2 intron. Comparative genomic analyses revealed that RTOM1, RTOM2, and RTOM3 are strongly conserved and are under purifying selection between these species. These could be generated by tandem duplications before the divergence of platypus and echidna. All RTOM transcripts were specifically expressed in the testis, possibly suggesting their physiological importance. This is the first study reporting monotreme-specific de novo gene candidates derived from ERVs, which provides new insights into the unique evolution of monotremes. | en |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press (OUP) | en |
dc.rights | © The Author(s) 2022. Published by Oxford University Press. | en |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | endogenous retrovirus | en |
dc.subject | monotreme | en |
dc.subject | reverse transcriptase | en |
dc.subject | virus-derived gene | en |
dc.title | Monotreme-Specific Conserved Putative Proteins Derived from Retroviral Reverse Transcriptase | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Virus Evolution | en |
dc.identifier.volume | 8 | - |
dc.identifier.issue | 2 | - |
dc.relation.doi | 10.1093/ve/veac084 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | veac084 | - |
dc.identifier.pmid | 36176487 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 20J22607 | - |
datacite.awardNumber | 20K06775 | - |
datacite.awardNumber | 20H03150 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20J22607/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K06775/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03150/ | - |
dc.identifier.eissn | 2057-1577 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 転写後遺伝子発現制御における内在性ウイルス由来配列の寄与 | ja |
jpcoar.awardTitle | 哺乳類ゲノムに内在化したレトロウイルス由来の遺伝子の進化メカニズムの解明 | ja |
jpcoar.awardTitle | 共生レトロウイルスの抗腫瘍ポテンシャルの解明と有効活用 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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