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ファイル | 記述 | サイズ | フォーマット | |
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BCJ20210557.pdf | 2.07 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Hirashima, Tsuyoshi | en |
dc.contributor.alternative | 平島, 剛志 | ja |
dc.date.accessioned | 2022-12-09T04:59:21Z | - |
dc.date.available | 2022-12-09T04:59:21Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.uri | http://hdl.handle.net/2433/277770 | - |
dc.description.abstract | The chemical and mechanical responses of cells via the exchange of information during growth and development result in the formation of biological tissues. Information processing within the cells through the signaling pathways and networks inherent to the constituent cells has been well-studied. However, the cell signaling mechanisms responsible for generating dynamic multicellular responses in developing tissues remain unclear. Here, I review the dynamic multicellular response systems during the development and growth of vertebrate tissues based on the extracellular signal-regulated kinase (ERK) pathway. First, an overview of the function of the ERK signaling network in cells is provided, followed by descriptions of biosensors essential for live imaging of the quantification of ERK activity in tissues. Then adducing four examples, I highlight the contribution of live imaging techniques for studying the involvement of spatio-temporal patterns of ERK activity change in tissue development and growth. In addition, theoretical implications of ERK signaling are also discussed from the viewpoint of dynamic systems. This review might help in understanding ERK-mediated dynamic multicellular responses and tissue morphogenesis. | en |
dc.language.iso | eng | - |
dc.publisher | Portland Press Ltd. | en |
dc.rights | © 2022 The Author(s) | en |
dc.rights | This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | ERK map kinase | en |
dc.subject | live imaging | en |
dc.subject | multicellular response | en |
dc.subject | tissue development | en |
dc.subject | Biochemical Techniques & Resources | en |
dc.subject | Biophysics | en |
dc.subject | Developmental Biology | en |
dc.subject | Systems Biology & Networks | en |
dc.title | Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Biochemical Journal | en |
dc.identifier.volume | 479 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 129 | - |
dc.identifier.epage | 143 | - |
dc.relation.doi | 10.1042/BCJ20210557 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 35050327 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 21H05290 | - |
datacite.awardNumber | 21H00426 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21H05290/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21H00426/ | - |
dc.identifier.pissn | 0264-6021 | - |
dc.identifier.eissn | 1470-8728 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 多細胞自律性を支える細胞競合機構の数理・物理学的解明 | ja |
jpcoar.awardTitle | 生殖細胞集団動態のシンギュラリティを生み出す運動能プロファイル | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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