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dc.contributor.authorSaito, Daisukeen
dc.contributor.authorTadokoro, Ryosukeen
dc.contributor.authorNagasaka, Arataen
dc.contributor.authorYoshino, Daisukeen
dc.contributor.authorTeramoto, Takayukien
dc.contributor.authorMizumoto, Kantaen
dc.contributor.authorFunamoto, Kenichien
dc.contributor.authorKidokoro, Hinakoen
dc.contributor.authorMiyata, Takakien
dc.contributor.authorTamura, Kojien
dc.contributor.authorTakahashi, Yoshikoen
dc.contributor.alternative齋藤, 大介ja
dc.contributor.alternative田所, 竜介ja
dc.contributor.alternative長坂, 新ja
dc.contributor.alternative吉野, 大輔ja
dc.contributor.alternative寺本, 孝行ja
dc.contributor.alternative水本, 堪大ja
dc.contributor.alternative船本, 健一ja
dc.contributor.alternative城所, 比奈子ja
dc.contributor.alternative宮田, 卓樹ja
dc.contributor.alternative田村, 宏治ja
dc.contributor.alternative高橋, 淑子ja
dc.date.accessioned2022-12-14T08:38:02Z-
dc.date.available2022-12-14T08:38:02Z-
dc.date.issued2022-12-22-
dc.identifier.urihttp://hdl.handle.net/2433/277820-
dc.description細胞の血行性転移の新たな仕組みを発見 --世界初、新たながん転移抑止戦略の開発にも期待--. 京都大学プレスリリース. 2022-12-13.ja
dc.description.abstractUnlike mammals, primordial germ cells (PGCs) in avian early embryos exploit blood circulation to translocate to the somatic gonadal primordium, but how circulating PGCs undergo extravasation remains elusive. We demonstrate with single-cell level live-imaging analyses that the PGCs are arrested at a specific site in the capillary plexus, which is predominantly governed by occlusion at a narrow path in the vasculature. The occlusion is enabled by a heightened stiffness of the PGCs mediated by actin polymerization. Following the occlusion, PGCs reset their stiffness to soften in order to squeeze through the endothelial lining as they transmigrate. Our discovery also provides a model for the understanding of metastasizing cancer extravasation occurring mainly by occlusion.en
dc.language.isoeng-
dc.publisherElsevier BVen
dc.rights© 2022 The Authors.en
dc.rightsThis is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectBiological sciencesen
dc.subjectCell biologyen
dc.subjectDevelopmental biologyen
dc.titleStiffness of primordial germ cells is required for their extravasation in avian embryosen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleiScienceen
dc.identifier.volume25-
dc.identifier.issue12-
dc.relation.doi10.1016/j.isci.2022.105629-
dc.textversionpublisher-
dc.identifier.artnum105629-
dc.addressFrontier Research Institute for Interdisciplinary Sciences, Tohoku University; Department of Ecological Developmental Adaptability Life Sciences, Graduate School of Life Sciences, Tohoku University; Department of Biology, Faculty of Science, Kyushu Universityen
dc.addressDepartment of Zoology, Graduate School of Science, Kyoto University; Department of Bioscience, Okayama University of Scienceen
dc.addressDivision of Histology, Meikai University School of Dentistry; Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicineen
dc.addressFrontier Research Institute for Interdisciplinary Sciences, Tohoku University; Institute of Engineering, Tokyo University of Agriculture and Technologyen
dc.addressDepartment of Biology, Faculty of Science, Kyushu Universityen
dc.addressDepartment of Zoology, Graduate School of Science, Kyoto Universityen
dc.addressInstitute of Fluid Science, Tohoku Universityen
dc.addressDepartment of Ecological Developmental Adaptability Life Sciences, Graduate School of Life Sciences, Tohoku University; Organization for Research Initiatives and Development, Doshisha Universityen
dc.addressDepartment of Anatomy and Cell Biology, Nagoya University Graduate School of Medicineen
dc.addressDepartment of Ecological Developmental Adaptability Life Sciences, Graduate School of Life Sciences, Tohoku Universityen
dc.addressDepartment of Zoology, Graduate School of Science, Kyoto Universityen
dc.identifier.pmid36465120-
dc.relation.urlhttps://www.kyoto-u.ac.jp/ja/research-news/2022-12-13-3-
dcterms.accessRightsopen access-
datacite.awardNumber23116705-
datacite.awardNumber25111719-
datacite.awardNumber15K14358-
datacite.awardNumber18H02445-
datacite.awardNumber20K21425-
datacite.awardNumber20H03259-
datacite.awardNumber19H04775-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23116705/-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-25111719/-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14358/-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02445/-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21425/-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03259/-
datacite.awardNumber.urihttps://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-19H04775/-
dc.identifier.eissn2589-0042-
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.funderName日本学術振興会ja
jpcoar.awardTitle始原生殖細胞を支える生殖巣外ニッチja
jpcoar.awardTitle血行性転移における動く細胞と場のクロストークja
jpcoar.awardTitle細胞弾性から読み解く血行性転移機構ja
jpcoar.awardTitle生殖細胞が胚体外に生じる意義を問うja
jpcoar.awardTitle収縮性オーガノイドを用いた腸蠕動運動の制御機構の解明ja
jpcoar.awardTitle血流メカノ刺激によって時空間的に連鎖・連動する器官形成のしくみja
jpcoar.awardTitle腸の蠕動運動に潜む時計機能の成立メカニズムja
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