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dc.contributor.authorShiomi, Kojien
dc.contributor.authorArakawa, Yoshikien
dc.contributor.authorMinamiguchi, Sachikoen
dc.contributor.authorYamashita, Harukien
dc.contributor.authorTerada, Yukinorien
dc.contributor.authorTanji, Masahiroen
dc.contributor.authorMineharu, Yoheien
dc.contributor.authorUmeda, Katsutsuguen
dc.contributor.authorUto, Megumien
dc.contributor.authorTakita, Junkoen
dc.contributor.authorHaga, Hironorien
dc.contributor.authorMizowaki, Takashien
dc.contributor.authorMiyamoto, Susumuen
dc.contributor.alternative塩見, 晃司ja
dc.contributor.alternative荒川, 芳輝ja
dc.contributor.alternative南口, 早智子ja
dc.contributor.alternative山下, 陽生ja
dc.contributor.alternative寺田, 行範ja
dc.contributor.alternative丹治, 正大ja
dc.contributor.alternative峰晴, 陽平ja
dc.contributor.alternative梅田, 雄嗣ja
dc.contributor.alternative宇藤, 恵ja
dc.contributor.alternative滝田, 順子ja
dc.contributor.alternative羽賀, 博典ja
dc.contributor.alternative溝脇, 尚志ja
dc.contributor.alternative宮本, 享ja
dc.date.accessioned2022-12-28T01:19:23Z-
dc.date.available2022-12-28T01:19:23Z-
dc.date.issued2021-03-
dc.identifier.urihttp://hdl.handle.net/2433/278209-
dc.description.abstractBACKGROUND: Tumors in the pineal region consist of various histological types, and correct diagnosis from biopsy specimens is sometimes difficult. The authors report the case of a patient with a mixed germ cell tumor infiltrating into the pineal gland despite showing no elevation of tumor markers. OBSERVATIONS: An 18-year-old man complained of headache and nausea and showed disturbance of consciousness. Magnetic resonance imaging showed hydrocephalus associated with a cystic pineal tumor. The patient underwent tumor biopsy followed by endoscopic third ventriculostomy for hydrocephalus in a local hospital. A pineocytoma was diagnosed, and the patient was referred to the authors' hospital for treatment. Concentrations of placental alkaline phosphatase, alpha-fetoprotein (AFP), and beta-human chorionic gonadotropin in cerebrospinal fluid were not elevated. However, the authors' review of the tumor specimen revealed some immature cells infiltrating the pineal gland. These cells were positive for AFP, Sal-like protein 4, and octamer-binding transcription factor 3/4; and the diagnosis was changed to mixed germ cell tumor. Chemoradiotherapy was initiated, followed by surgical removal of the residual tumor. LESSONS: Careful examination of all tumor specimens and immunohistochemical analyses are important for accurate diagnosis of pineal tumors.en
dc.language.isoeng-
dc.publisherAmerican Association of Neurological Surgeonsen
dc.rights© 2021 The authorsen
dc.rightsCC BY-NC-ND 4.0en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectmixed germ cell tumoren
dc.subjectimmunohistochemistryen
dc.subjecthistological diagnosisen
dc.subjectpineocytomaen
dc.subjectpineal parenchymal tumor of intermediate differentiationen
dc.titleMixed germ cell tumor infiltrating the pineal gland without elevated tumor markers: illustrative caseen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleJournal of Neurosurgery. Case Lessonsen
dc.identifier.volume1-
dc.identifier.issue12-
dc.relation.doi10.3171/CASE20131-
dc.textversionpublisher-
dc.identifier.artnumCASE20131-
dc.identifier.pmid35854926-
dc.relation.urlhttps://thejns.org/caselessons/view/journals/j-neurosurg-case-lessons/1/12/article-CASE20131.xml-
dcterms.accessRightsopen access-
dc.identifier.eissn2694-1902-
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