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eLife.79461.pdf | 11.64 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Kanaoka, Yasutetsu | en |
dc.contributor.author | Onodera, Koun | en |
dc.contributor.author | Watanabe, Kaori | en |
dc.contributor.author | Hayashi, Yusaku | en |
dc.contributor.author | Usui, Tadao | en |
dc.contributor.author | Uemura, Tadashi | en |
dc.contributor.author | Hattori, Yukako | en |
dc.contributor.alternative | 金岡, 泰哲 | ja |
dc.contributor.alternative | 小野寺, 孝興 | ja |
dc.contributor.alternative | 渡邉, 佳織 | ja |
dc.contributor.alternative | 林, 優作 | ja |
dc.contributor.alternative | 碓井, 理夫 | ja |
dc.contributor.alternative | 上村, 匡 | ja |
dc.contributor.alternative | 服部, 佑佳子 | ja |
dc.date.accessioned | 2023-01-26T02:11:15Z | - |
dc.date.available | 2023-01-26T02:11:15Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | http://hdl.handle.net/2433/278855 | - |
dc.description | 低栄養なのに神経細胞は成長する? --栄養に応じて分岐を制御する神経−筋肉連関--. 京都大学プレスリリース. 2023-01-24. | ja |
dc.description | Fruit flies grow brainy on a poor diet: Inter-organ signaling regulates nutrient-dependent hyperarborization of neurons in Drosophila. 京都大学プレスリリース. 2023-01-18. | en |
dc.description.abstract | Nutrition in early life has profound effects on an organism, altering processes such as organogenesis. However, little is known about how specific nutrients affect neuronal development. Dendrites of class IV dendritic arborization neurons in Drosophila larvae become more complex when the larvae are reared on a low-yeast diet compared to a high-yeast diet. Our systematic search for key nutrients revealed that the neurons increase their dendritic terminal densities in response to a combined deficiency in vitamins, metal ions, and cholesterol. The deficiency of these nutrients upregulates Wingless in a closely located tissue, body wall muscle. Muscle-derived Wingless activates Akt in the neurons through the receptor tyrosine kinase Ror, which promotes the dendrite branching. In larval muscles, the expression of wingless is regulated not only in this key nutrient-dependent manner, but also by the JAK/STAT signaling pathway. Additionally, the low-yeast diet blunts neuronal light responsiveness and light avoidance behavior, which may help larvae optimize their survival strategies under low-nutritional conditions. Together, our studies illustrate how the availability of specific nutrients affects neuronal development through inter-organ signaling. | en |
dc.language.iso | eng | - |
dc.publisher | eLife Sciences Publications, Ltd | en |
dc.rights | © 2023, Kanaoka et al. | en |
dc.rights | This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Research Article | en |
dc.subject | Developmental Biology | en |
dc.subject | Neuroscience | en |
dc.subject | nutrition | en |
dc.subject | somatosensory neuron | en |
dc.subject | dendritic morphology | en |
dc.subject | inter-organ signaling | en |
dc.subject | wingless | en |
dc.subject | Drosophila | en |
dc.title | Inter-organ Wingless/Ror/Akt signaling regulates nutrient-dependent hyperarborization of somatosensory neurons | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | eLife | en |
dc.identifier.volume | 12 | - |
dc.relation.doi | 10.7554/eLife.79461 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | e79461 | - |
dc.address | Graduate School of Biostudies, Kyoto University | en |
dc.address | Graduate School of Biostudies, Kyoto University | en |
dc.address | Graduate School of Biostudies, Kyoto University | en |
dc.address | Graduate School of Biostudies, Kyoto University | en |
dc.address | Graduate School of Biostudies, Kyoto University | en |
dc.address | Graduate School of Biostudies, Kyoto University; Research Center for Dynamic Living Systems, Kyoto University; AMED-CREST | en |
dc.address | Graduate School of Biostudies, Kyoto University; JST FOREST | en |
dc.identifier.pmid | 36647607 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2023-01-24-1 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/en/research-news/2023-01-18 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 15H02400 | - |
datacite.awardNumber | 21H00251 | - |
datacite.awardNumber | 21K06186 | - |
datacite.awardNumber | 20J15084 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02400/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21H00251/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K06186/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20J15084/ | - |
dc.identifier.eissn | 2050-084X | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 栄養状態に応答して神経細胞の成長を調節する器官間相互作用 | ja |
jpcoar.awardTitle | 栄養環境に応じた個体成長および生殖機能を支えるクロマチン制御機構の解明 | ja |
jpcoar.awardTitle | 共生酵母・細菌由来代謝産物による宿主成長の分子機構解明 | ja |
jpcoar.awardTitle | 栄養依存的な神経突起の発達メカニズムと個体の生理機能に果たす意義の追究 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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