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dc.contributor.author | Fujiyoshi, Haruna | en |
dc.contributor.author | Egawa, Tatsuro | en |
dc.contributor.author | Kurogi, Eriko | en |
dc.contributor.author | Yokokawa, Takumi | en |
dc.contributor.author | Kido, Kohei | en |
dc.contributor.author | Hayashi, Tatsuya | en |
dc.contributor.alternative | 藤吉, 春菜 | ja |
dc.contributor.alternative | 江川, 達郎 | ja |
dc.contributor.alternative | 黒木, 英梨子 | ja |
dc.contributor.alternative | 横川, 拓海 | ja |
dc.contributor.alternative | 木戸, 康平 | ja |
dc.contributor.alternative | 林, 達也 | ja |
dc.date.accessioned | 2023-01-27T06:32:44Z | - |
dc.date.available | 2023-01-27T06:32:44Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.uri | http://hdl.handle.net/2433/278907 | - |
dc.description.abstract | Endurance exercise induces various adaptations that yield health benefits; however, the underlying molecular mechanism has not been fully elucidated. Given that it has recently been accepted that inflammatory responses are required for a specific muscle adaptation after exercise, this study investigated whether toll-like receptor (TLR) 4, a pattern recognition receptor that induces proinflammatory cytokines, is responsible for exercise-induced adaptations in mouse skeletal muscle. The TLR4 mutant (TLR4m) and intact TLR4 control mice were each divided into 2 groups (sedentary and voluntary wheel running) and were housed for six weeks. Next, we removed the plantaris muscle and evaluated the expression of cytokines and muscle regulators. Exercise increased cytokine expression in the controls, whereas a smaller increase was observed in the TLR4m mice. Mitochondrial markers and mitochondrial biogenesis inducers, including peroxisome proliferator-activated receptor beta and heat shock protein 72, were increased in the exercised controls, whereas this upregulation was attenuated in the TLR4m mice. In contrast, exercise increased the expression of molecules such as peroxisome proliferator-activated receptor-gamma coactivator 1-alpha and glucose transporter 4 in both the controls and TLR4m mice. Our findings indicate that exercise adaptations such as mitochondrial biogenesis are mediated via TLR4, and that TLR4-mediated inflammatory responses could be involved in the mechanism of adaptation. | en |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | en |
dc.rights | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.rights | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | endurance exercise | en |
dc.subject | inflammation | en |
dc.subject | mitochondrial biogenesis | en |
dc.subject | PPAR | en |
dc.subject | HSP72 | en |
dc.title | TLR4-Mediated Inflammatory Responses Regulate Exercise-Induced Molecular Adaptations in Mouse Skeletal Muscle | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | International Journal of Molecular Sciences | en |
dc.identifier.volume | 23 | - |
dc.identifier.issue | 3 | - |
dc.relation.doi | 10.3390/ijms23031877 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 1877 | - |
dc.identifier.pmid | 35163799 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 18H03148 | - |
datacite.awardNumber | 19K22806 | - |
datacite.awardNumber | 18J01392 | - |
datacite.awardNumber | 19K20007 | - |
datacite.awardNumber | 16J10577 | - |
datacite.awardNumber | 19K11520 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H03148/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22806/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18J01392/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K20007/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16J10577/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K11520/ | - |
dc.identifier.eissn | 1422-0067 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 糖化ストレスによる運動トレーニング効果の抑制作用の検証 --糖化研究基盤確立に向けて | ja |
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jpcoar.awardTitle | 筋収縮によって即時的に活性化される骨格筋糖輸送を増強・減弱する因子とその分子機構 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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