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dc.contributor.author | Sakamoto, Ryota | en |
dc.contributor.author | Izri, Ziane | en |
dc.contributor.author | Shimamoto, Yuta | en |
dc.contributor.author | Miyazaki, Makito | en |
dc.contributor.author | Maeda, Yusuke T. | en |
dc.contributor.alternative | 坂本, 遼太 | ja |
dc.contributor.alternative | 島本, 勇太 | ja |
dc.contributor.alternative | 宮﨑, 牧人 | ja |
dc.contributor.alternative | 前多, 裕介 | ja |
dc.date.accessioned | 2023-01-29T23:58:18Z | - |
dc.date.available | 2023-01-29T23:58:18Z | - |
dc.date.issued | 2022-07-26 | - |
dc.identifier.uri | http://hdl.handle.net/2433/278933 | - |
dc.description | 動きまわる人工細胞、その鍵は摩擦にあり --細胞が狭い空間を利用して運動する仕組みを解明--. 京都大学プレスリリース. 2022-07-21. | ja |
dc.description.abstract | Cell migration in confined environments is fundamental for diverse biological processes from cancer invasion to leukocyte trafficking. The cell body is propelled by the contractile force of actomyosin networks transmitted from the cell membrane to the external substrates. However, physical determinants of actomyosin-based migration capacity in confined environments are not fully understood. Here, we develop an in vitro migratory cell model, where cytoplasmic actomyosin networks are encapsulated into droplets surrounded by a lipid monolayer membrane. We find that the droplet can move when the actomyosin networks are bound to the membrane, in which the physical interaction between the contracting actomyosin networks and the membrane generates a propulsive force. The droplet moves faster when it has a larger contact area with the substrates, while narrower confinement reduces the migration speed. By combining experimental observations and active gel theory, we propose a mechanism where the balance between sliding friction force, which is a reaction force of the contractile force, and viscous drag determines the migration speed, providing a physical basis of actomyosin-based motility in confined environments. | en |
dc.language.iso | eng | - |
dc.publisher | Proceedings of the National Academy of Sciences | en |
dc.rights | Copyright © 2022 the Author(s). Published by PNAS. | en |
dc.rights | This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | ACTIN CYTOSKELETON | en |
dc.subject | RECONSTITUTED SYSTEMS | en |
dc.subject | MICROFLUIDICS | en |
dc.subject | CELL MIGRATION | en |
dc.subject | ACTIVE GELS | en |
dc.title | Geometric trade-off between contractile force and viscous drag determines the actomyosin-based motility of a cell-sized droplet | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Proceedings of the National Academy of Sciences | en |
dc.identifier.volume | 119 | - |
dc.identifier.issue | 30 | - |
dc.relation.doi | 10.1073/pnas.2121147119 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | e2121147119 | - |
dc.address | Department of Physics, Graduate School of Science, Kyushu University | en |
dc.address | School of Physics and Astronomy, University of Minnesota | en |
dc.address | Department of Chromosome Science, National Institute of Genetics | en |
dc.address | Hakubi Center for Advanced Research, Kyoto University; Department of Physics, Graduate School of Science, Kyoto University; Institut Curie, Paris Sciences et Lettres Research University; PRESTO, Japan Science and Technology Agency | en |
dc.address | Department of Physics, Graduate School of Science, Kyushu University | en |
dc.identifier.pmid | 35857875 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2022-07-21-2 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 20H01872 | - |
datacite.awardNumber | 19H03201 | - |
datacite.awardNumber | 18H05427 | - |
datacite.awardNumber | 19H05393 | - |
datacite.awardNumber | 19J20035 | - |
datacite.awardNumber | 21K18605 | - |
datacite.awardNumber | 20K21404 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H01872/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03201/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-18H05427/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-19H05393/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19J20035/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K18605/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21404/ | - |
dc.identifier.pissn | 0027-8424 | - |
dc.identifier.eissn | 1091-6490 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | アクティブマターのキラルな秩序渦と乱流状態の幾何的普遍性の研究 | ja |
jpcoar.awardTitle | 分裂期染色体とその構築因子の力学感受メカニズム | ja |
jpcoar.awardTitle | 発動分子の自律的運動と機能設計のエネルギー論的研究 | ja |
jpcoar.awardTitle | 生体発動分子を利用した自己駆動型人工細胞の開発と理論解析による機能の最適化 | ja |
jpcoar.awardTitle | 生体分子モーターが躍動する非平衡界面と細胞の破れた対称性の物理学 | ja |
jpcoar.awardTitle | アクティブゲルで切り拓く細胞の対称性と運動原理の非平衡力学 | ja |
jpcoar.awardTitle | 新規力計測プローブを用いた哺乳類卵母細胞の紡錘体エラー発生メカニズムの探究 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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