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タイトル: | Hemodynamic and Histopathological Changes in the Early Phase of the Development of an Intracranial Aneurysm |
著者: | KATAOKA, Hiroharu YAGI, Takanobu IKEDO, Taichi IMAI, Hirohiko https://orcid.org/0000-0002-6957-0031 (unconfirmed) KAWAMURA, Koichi YOSHIDA, Kazumichi NAKAMURA, Masanori AOKI, Tomohiro MIYAMOTO, Susumu |
著者名の別形: | 片岡, 大治 池堂, 太一 今井, 宏彦 吉田, 和道 宮本, 享 |
キーワード: | intracranial aneurysm hemodynamics internal elastic lamina smooth muscle cell |
発行日: | 2020 |
出版者: | Japan Neurosurgical Society |
誌名: | Neurologia medico-chirurgica |
巻: | 60 |
号: | 7 |
開始ページ: | 319 |
終了ページ: | 328 |
抄録: | Hemodynamic stress and chronic inflammation are closely associated with the pathogenesis of intracranial aneurysms (IAs). However, the hemodynamic and biological mechanisms triggering IA formation remain to be elucidated. To clarify them, computational fluid dynamics (CFD) and histopathological analyses in the early phase of IA development using an experimentally induced IA model in rats were conducted. Histological changes in the early phase of IA development were observed under a scanning electron microscope (SEM) and a transmission electron microscope (TEM). Using data from 7-T magnetic resonance angiography (7T-MRA), CFD analyses were performed to determine wall shear stress (WSS) and wall pressure (WP) at the prospective site of IA. A bump-like protrusion named an “intimal pad” was located in the anterior cerebral artery (ACA) immediately distal to the apex of the bifurcation. TEM showed the degeneration of the internal elastic lamina (IEL) and longitudinally elongated smooth muscle cells (SMCs) that switched from the contractile to the proliferative phenotype and penetrated between two divided layers of the degenerated IEL in the prospective site of the IA. However, no inflammatory cells were observed. CFD analyses showed no particular pattern of WSS and WP at the prospective IA site. IEL degeneration and the phenotypic change and longitudinal elongation of SMCs were identified as the early events in IA development. CFD analyses and TEM data suggest that these biological events may be derived from increased circumferential wall stress due to increased blood pressure and increased longitudinal wall strain due to the existence of the intimal pad. |
著作権等: | © 2020 by The Japan Neurosurgical Society This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. |
URI: | http://hdl.handle.net/2433/279968 |
DOI(出版社版): | 10.2176/nmc.st.2020-0072 |
PubMed ID: | 32536660 |
出現コレクション: | 学術雑誌掲載論文等 |
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