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j.xgen.2023.100292.pdf | 15.95 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Chen, Xun | en |
dc.contributor.author | Pacis, Alain | en |
dc.contributor.author | Aracena, Katherine A. | en |
dc.contributor.author | Gona, Saideep | en |
dc.contributor.author | Kwan, Tony | en |
dc.contributor.author | Groza, Cristian | en |
dc.contributor.author | Lin, Yen Lung | en |
dc.contributor.author | Sindeaux, Renata | en |
dc.contributor.author | Yotova, Vania | en |
dc.contributor.author | Pramatarova, Albena | en |
dc.contributor.author | Simon, Marie-Michelle | en |
dc.contributor.author | Pastinen, Tomi | en |
dc.contributor.author | Barreiro, Luis B. | en |
dc.contributor.author | Bourque, Guillaume | en |
dc.date.accessioned | 2023-05-15T08:16:14Z | - |
dc.date.available | 2023-05-15T08:16:14Z | - |
dc.date.issued | 2023-05-10 | - |
dc.identifier.uri | http://hdl.handle.net/2433/282091 | - |
dc.description | インフルエンザ重症度に関連する転移因子を特定: マルチオミクス解析で見えた「動く遺伝子」の新たな役割. 京都大学プレスリリース. 2023-05-11. | ja |
dc.description | A multiomics approach provides insights into flu severity. 京都大学プレスリリース. 2023-05-11. | en |
dc.description.abstract | Influenza A virus (IAV) infections are frequent every year and result in a range of disease severity. Here, we wanted to explore the potential contribution of transposable elements (TEs) to the variable human immune response. Transcriptome profiling in monocyte-derived macrophages from 39 individuals following IAV infection revealed significant inter-individual variation in viral load post-infection. Using transposase-accessible chromatin using sequencing (ATAC-seq), we identified a set of TE families with either enhanced or reduced accessibility upon infection. Of the enhanced families, 15 showed high variability between individuals and had distinct epigenetic profiles. Motif analysis showed an association with known immune regulators (e.g., BATFs, FOSs/JUNs, IRFs, STATs, NFkBs, NFYs, and RELs) in stably enriched families and with other factors in variable families, including KRAB-ZNFs. We showed that TEs and host factors regulating TEs were predictive of viral load post-infection. Our findings shed light on the role TEs and KRAB-ZNFs may play in inter-individual variation in immunity. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2023 The Authors. | en |
dc.rights | This is an open access article under the CC BY-NC-ND license. | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | transposable elements | en |
dc.subject | Kruppel-associated box zinc finger proteins (KRAB-ZNFs) | en |
dc.subject | influenza infection | en |
dc.subject | variable response | en |
dc.subject | epigenetics | en |
dc.subject | gene regulation | en |
dc.title | Transposable elements are associated with the variable response to influenza infection | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Cell Genomics | en |
dc.identifier.volume | 3 | - |
dc.identifier.issue | 5 | - |
dc.relation.doi | 10.1016/j.xgen.2023.100292 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 100292 | - |
dc.address | Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University | en |
dc.address | Canadian Center for Computational Genomics, McGill University | en |
dc.address | Department of Human Genetics, University of Chicago | en |
dc.address | Department of Human Genetics, University of Chicago | en |
dc.address | Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University | en |
dc.address | Quantitative Life Science, McGill University | en |
dc.address | Department of Human Genetics, University of Chicago | en |
dc.address | Centre de Recherche, CHU Sainte-Justine, Université de Montréal | fr |
dc.address | Centre de Recherche, CHU Sainte-Justine, Université de Montréal | fr |
dc.address | Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University | en |
dc.address | Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University | en |
dc.address | Genomic Medicine Center, Children's Mercy Hospital and Research Institute; Department of Human Genetics, McGill University | en |
dc.address | Department of Human Genetics, University of Chicago; Section of Genetic Medicine, Department of Medicine, University of Chicago; Committee on Immunology, University of Chicago | en |
dc.address | Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University; Canadian Center for Computational Genomics, McGill University; Victor Phillip Dahdaleh Institute of Genomic Medicine at McGill University; Department of Human Genetics, McGill University | en |
dc.identifier.pmid | 37228757 | - |
dc.relation.url | https://ashbi.kyoto-u.ac.jp/ja/news/20230510_research-result_xun-chen/ | - |
dc.relation.url | https://ashbi.kyoto-u.ac.jp/news/20230510_research-result_xun-chen/ | - |
dcterms.accessRights | open access | - |
dc.identifier.eissn | 2666-979X | - |
出現コレクション: | 学術雑誌掲載論文等 |
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