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| Title: | Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants |
| Authors: | Tamura, Tomokazu Ito, Jumpei Uriu, Keiya Zahradnik, Jiri Kida, Izumi Anraku, Yuki Nasser, Hesham Shofa, Maya Oda, Yoshitaka Lytras, Spyros Nao, Naganori Itakura, Yukari Deguchi, Sayaka Suzuki, Rigel Wang, Lei Begum, MST Monira Kita, Shunsuke Yajima, Hisano Sasaki, Jiei Sasaki-Tabata, Kaori Shimizu, Ryo Tsuda, Masumi Kosugi, Yusuke Fujita, Shigeru Pan, Lin Sauter, Daniel Yoshimatsu, Kumiko Suzuki, Saori Asakura, Hiroyuki Nagashima, Mami Sadamasu, Kenji Yoshimura, Kazuhisa Yamamoto, Yuki Nagamoto, Tetsuharu Schreiber, Gideon Maenaka, Katsumi The Genotype to Phenotype Japan (G2P-Japan) Hashiguchi, Takao    https://orcid.org/0000-0001-7578-7571 (unconfirmed)Ikeda, Terumasa Fukuhara, Takasuke Saito, Akatsuki Tanaka, Shinya Matsuno, Keita Takayama, Kazuo https://orcid.org/0000-0002-1132-2457 (unconfirmed)Sato, Kei |
| Author's alias: | 田村, 友和 伊東, 潤平 瓜生, 慧也 紀田, 泉 安楽, 佑樹 小田, 義崇 直, 亨則 板倉, 友香里 出口, 清香 鈴木, 理滋 王, 磊 喜多, 俊介 矢島, 久乃 佐々木, 慈英 田畑, 香織 清水, 凌 津田, 真寿美 小杉, 優介 藤田, 滋 潘, 琳 吉松, 組子 鈴木, 紗織 浅倉, 弘幸 長島, 真美 貞升, 健志 吉村, 和久 山本, 佑樹 永元, 哲治 前仲, 勝実 橋口, 隆生 池田, 輝政 福原, 崇介 齊藤, 暁 田中, 伸哉 松野, 啓太 高山, 和雄 佐藤, 佳 |
| Keywords: | SARS-CoV-2 Viral evolution Virus–host interactions |
| Issue Date: | 2023 |
| Publisher: | Springer Nature |
| Journal title: | Nature Communications |
| Volume: | 14 |
| Thesis number: | 2800 |
| Abstract: | In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during the summer of 2022. XBB.1 is the variant most profoundly resistant to BA.2/5 breakthrough infection sera to date and is more fusogenic than BA.2.75. The recombination breakpoint is located in the receptor-binding domain of spike, and each region of the recombinant spike confers immune evasion and increases fusogenicity. We further provide the structural basis for the interaction between XBB.1 spike and human ACE2. Finally, the intrinsic pathogenicity of XBB.1 in male hamsters is comparable to or even lower than that of BA.2.75. Our multiscale investigation provides evidence suggesting that XBB is the first observed SARS-CoV-2 variant to increase its fitness through recombination rather than substitutions. |
| Description: | オミクロンXBB株の進化経路とウイルス学的特性の解明 --遺伝子組換えによる更なる免疫逃避能力の獲得--. 京都大学プレスリリース. 2023-05-22. |
| Rights: | © The Author(s) 2023 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
| URI: | http://hdl.handle.net/2433/282776 |
| DOI(Published Version): | 10.1038/s41467-023-38435-3 |
| PubMed ID: | 37193706 |
| Related Link: | https://www.kyoto-u.ac.jp/ja/research-news/2023-05-22-1 |
| Appears in Collections: | Journal Articles |
This item is licensed under a Creative Commons License
