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dc.contributor.authorWatanabe, Yukioen
dc.contributor.authorKimura, Izumien
dc.contributor.authorHashimoto, Rinaen
dc.contributor.authorSakamoto, Ayakaen
dc.contributor.authorYasuhara, Naokoen
dc.contributor.authorYamamoto, Takuyaen
dc.contributor.authorGenotype to Phenotype Japan (GP-Japan) Consortiumen
dc.contributor.authorSato, Keien
dc.contributor.authorTakayama, Kazuoen
dc.contributor.alternative渡邉, 幸夫ja
dc.contributor.alternative木村, 出海ja
dc.contributor.alternative橋本, 里菜ja
dc.contributor.alternative坂本, 綾香ja
dc.contributor.alternative山本, 拓也ja
dc.contributor.alternative佐藤, 佳ja
dc.contributor.alternative高山, 和雄ja
dc.date.accessioned2023-06-09T00:09:59Z-
dc.date.available2023-06-09T00:09:59Z-
dc.date.issued2023-06-
dc.identifier.urihttp://hdl.handle.net/2433/283266-
dc.descriptionヒトiPS細胞由来大腸オルガノイドおよびヒトケラチノサイトを用いたmpoxウイルス2022年株の解析. 京都大学プレスリリース. 2023-06-07.ja
dc.description.abstractThe outbreak-causing monkeypox virus of 2022 (2022 MPXV) is classified as a clade IIb strain and phylogenetically distinct from prior endemic MPXV strains (clades I or IIa), suggesting that its virological properties may also differ. Here, we used human keratinocytes and induced pluripotent stem cell-derived colon organoids to examine the efficiency of viral growth in these cells and the MPXV infection-mediated host responses. MPXV replication was much more productive in keratinocytes than in colon organoids. We observed that MPXV infections, regardless of strain, caused cellular dysfunction and mitochondrial damage in keratinocytes. Notably, a significant increase in the expression of hypoxia-related genes was observed specifically in 2022 MPXV-infected keratinocytes. Our comparison of virological features between 2022 MPXV and prior endemic MPXV strains revealed signaling pathways potentially involved with the cellular damages caused by MPXV infections and highlights host vulnerabilities that could be utilized as protective therapeutic strategies against human mpox in the future.en
dc.language.isoeng-
dc.publisherWileyen
dc.rights© 2023 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.en
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/-
dc.subject2022 MPXV (clade IIb)en
dc.subjectcolon organoidsen
dc.subjectCongo Basin clade (clade I)en
dc.subjectkeratinocytesen
dc.subjectmonkeypox virusen
dc.subjectWest African clade (clade IIa)en
dc.titleVirological characterization of the 2022 outbreak-causing monkeypox virus using human keratinocytes and colon organoidsen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleJournal of Medical Virologyen
dc.identifier.volume95-
dc.identifier.issue6-
dc.relation.doi10.1002/jmv.28827-
dc.textversionpublisher-
dc.identifier.artnume28827-
dc.addressCenter for iPS Cell Research and Application (CiRA)en
dc.addressDivision of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyoen
dc.addressCenter for iPS Cell Research and Application (CiRA)en
dc.addressCenter for iPS Cell Research and Application (CiRA)en
dc.addressCenter for iPS Cell Research and Application (CiRA)en
dc.addressCenter for iPS Cell Research and Application (CiRA); Medical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP); Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto Universityen
dc.addressDivision of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo; Graduate School of Medicine, The University of Tokyo; International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo; Graduate School of Frontier Sciences, The University of Tokyo; Collaboration Unit for Infection, Joint Research Center for Human Retrovirus Infection, Kumamoto University; CREST, Japan Science and Technology Agencyen
dc.addressCenter for iPS Cell Research and Application (CiRA); AMED-CREST, Japan Agency for Medical Research and Development (AMED)en
dc.identifier.pmid37278443-
dc.relation.urlhttps://www.cira.kyoto-u.ac.jp/j/pressrelease/news/230607-100000.html-
dcterms.accessRightsopen access-
dc.identifier.pissn0146-6615-
dc.identifier.eissn1096-9071-
出現コレクション:学術雑誌掲載論文等

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