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タイトル: Chromosomal integration of blaCTX-M genes in diverse Escherichia coli isolates recovered from river water in Japan
著者: Gomi, Ryota  KAKEN_id  orcid https://orcid.org/0000-0002-3299-333X (unconfirmed)
Yamamoto, Masaki  kyouindb  KAKEN_id
Tanaka, Michio
Matsumura, Yasufumi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-8595-8944 (unconfirmed)
著者名の別形: 五味, 良太
山本, 正樹
田中, 美智男
松村, 康史
キーワード: Escherichia coli
blaCTX-M
genome sequencing
antibiotic resistance
river water
one health
発行日: 2022
出版者: Elsevier BV
誌名: Current Research in Microbial Sciences
巻: 3
論文番号: 100144
抄録: Occurrence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBLEC) in environmental waters is of great concern. However, unlike clinical ESBLEC, their genetic characteristics, in particular the genetic contexts of ESBL genes, are not well understood. In this study, we sequenced and analyzed the genomes of CTX-M-producing E. coli isolates recovered from river water to fully characterize the genetic contexts of blaCTX-M genes. Among the 14 isolates with completed genomes, blaCTX-M genes were detected on the chromosome in nine isolates. All but one chromosomal blaCTX-M genes were associated with ISEcp1 and were carried on different transposition units ranging in size from 2, 855 bp to 11, 093 bp; the exception, blaCTX-M-2, was associated with ISCR1. The remaining five isolates carried blaCTX-M genes on epidemic IncI1 plasmids of different sequence types (STs) (ST3, ST16, ST113, and ST167) (n = 4) or on an IncB/O/K/Z plasmid (n = 1). This study revealed that environmental E. coli carry blaCTX-M genes in diverse genetic contexts. Apparent high prevalence of chromosomal blaCTX-M potentially indicates that some E. coli can stably maintain blaCTX-M genes in environmental waters, though further studies are needed to confirm this.
著作権等: © 2022 The Authors. Published by Elsevier B.V.
This is an open access article under the CC BY license.
URI: http://hdl.handle.net/2433/283905
DOI(出版社版): 10.1016/j.crmicr.2022.100144
PubMed ID: 35909619
出現コレクション:学術雑誌掲載論文等

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