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j.isci.2023.106416.pdf | 4.73 MB | Adobe PDF | 見る/開く |
タイトル: | Wnt/β-catenin signaling induces axial elasticity patterns of Hydra extracellular matrix |
著者: | Veschgini, Mariam Suzuki, Ryo https://orcid.org/0000-0002-7603-2194 (unconfirmed) Kling, Svenja Petersen, O., Hendrik Bergheim, Gideon, Bruno Abuillan, Wasim Linke, Philipp Kaufmann, Stefan Burghammer, Manfred Engel, Ulrike Stein, Frank Özbek, Suat Holstein, W., Thomas Tanaka, Motomu https://orcid.org/0000-0003-3663-9554 (unconfirmed) |
著者名の別形: | 鈴木, 量 田中, 求 |
キーワード: | Histology Microscopic anatomy Zoology Molecular biology |
発行日: | Apr-2023 |
出版者: | Elsevier BV |
誌名: | iScience |
巻: | 26 |
号: | 4 |
論文番号: | 106416 |
抄録: | The extracellular matrix (ECM) plays crucial roles in animal development and diseases. Here, we report that Wnt/β-catenin signaling induces the ECM remodeling during Hydra axis formation. We determined the micro- and nanoscopic arrangement of fibrillar type I collagen along Hydra’s body axis using high-resolution microscopy and X-ray scattering. Elasticity mapping of the ECM ex vivo revealed distinctive elasticity patterns along the body axis. A proteomic analysis of the ECM showed that these elasticity patterns correlate with a gradient-like distribution of metalloproteases along the body axis. Activation of the Wnt/β-catenin pathway in wild-type and transgenic animals alters these patterns toward low ECM elasticity patterns. This suggests a mechanism whereby high protease activity under control of Wnt/β-catenin signaling causes remodeling and softening of the ECM. This Wnt-dependent spatiotemporal coordination of biochemical and biomechanical cues in ECM formation was likely a central evolutionary innovation for animal tissue morphogenesis. |
著作権等: | © 2023 The Authors. This is an open access article under the CC BY-NC-ND license. |
URI: | http://hdl.handle.net/2433/284912 |
DOI(出版社版): | 10.1016/j.isci.2023.106416 |
PubMed ID: | 37009232 |
出現コレクション: | 学術雑誌掲載論文等 |
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