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j.cdev.2023.203845.pdf | 3.85 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Tanaka, Motomu | en |
dc.contributor.author | Thoma, Judith | en |
dc.contributor.author | Poisa-Beiro, Laura | en |
dc.contributor.author | Wuchter, Patrick | en |
dc.contributor.author | Eckstein, Volker | en |
dc.contributor.author | Dietrich, Sascha | en |
dc.contributor.author | Pabst, Caroline | en |
dc.contributor.author | Müller-Tidow, Carsten | en |
dc.contributor.author | Ohta, Takao | en |
dc.contributor.author | Ho, Anthony D. | en |
dc.contributor.alternative | 田中, 求 | ja |
dc.date.accessioned | 2023-09-04T00:31:05Z | - |
dc.date.available | 2023-09-04T00:31:05Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.uri | http://hdl.handle.net/2433/284913 | - |
dc.description.abstract | Adhesion of hematopoietic stem and progenitor cells (HSPCs) to the bone marrow niche plays critical roles in the maintenance of the most primitive HSPCs. The interactions of HSPC−niche interactions are clinically relevant in acute myeloid leukemia (AML), because (i) leukemia-initiating cells adhered to the marrow niche are protected from the cytotoxic effect by chemotherapy and (ii) mobilization of HSPCs from healthy donors' bone marrow is crucial for the effective stem cell transplantation. However, although many clinical agents have been developed for the HSPC mobilization, the effects caused by the extrinsic molecular cues were traditionally evaluated based on phenomenological observations. This review highlights the recent interdisciplinary challenges of hematologists, biophysicists and cell biologists towards the design of defined in vitro niche models and the development of physical biomarkers for quantitative indexing of differential effects of clinical agents on human HSPCs. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2023 The Authors. Published by Elsevier B.V. | en |
dc.rights | This is an open access article under the CC BY-NC-ND license. | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Human hematopoietic stem and progenitor cell | en |
dc.subject | Acute myeloid leukemia | en |
dc.subject | Celsl adhesion | en |
dc.subject | Spatio-temporal dynamics | en |
dc.subject | Clinical agent | en |
dc.title | Physical biomarkers for human hematopoietic stem and progenitor cells | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Cells & Development | en |
dc.identifier.volume | 174 | - |
dc.relation.doi | 10.1016/j.cdev.2023.203845 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 203845 | - |
dc.identifier.pmid | 37116713 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 20H00661 | - |
datacite.awardNumber | 19H05719 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00661/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-19H05719/ | - |
dc.identifier.eissn | 2667-2901 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | がん細胞・オルガノイドの動態を基盤とする物理的バイオマーカーの創出 | ja |
jpcoar.awardTitle | 水圏機能材料の電子・イオン機能開拓 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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