ダウンロード数: 115
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
sciadv.adh2154.pdf | 2.56 MB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Tsuboi, Alice | en |
dc.contributor.author | Fujimoto, Koichi | en |
dc.contributor.author | Kondo, Takefumi | en |
dc.contributor.alternative | 坪井, 有寿 | ja |
dc.contributor.alternative | 藤本, 仰一 | ja |
dc.contributor.alternative | 近藤, 武史 | ja |
dc.date.accessioned | 2023-09-04T02:59:41Z | - |
dc.date.available | 2023-09-04T02:59:41Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.uri | http://hdl.handle.net/2433/284920 | - |
dc.description | 細胞シートを3次元に折れたたむ仕組み発見 --接着素材の構築・解体が正確な生体組織の「折り紙」を実現--. 京都大学プレスリリース. 2023-09-04. | ja |
dc.description | Unveiling the mechanism of 3D folding of cell sheets: Constructing and disassembling adhesive materials for precise origami of tissues. 京都大学プレスリリース. 2023-09-07. | en |
dc.description.abstract | Biological systems are inherently noisy; however, they produce highly stereotyped tissue morphology. Drosophila pupal wings show a highly stereotypic folding through uniform expansion and subsequent buckling of wing epithelium within a surrounding cuticle sac. The folding pattern produced by buckling is generally stochastic; it is thus unclear how buckling leads to stereotypic tissue folding of the wings. We found that the extracellular matrix (ECM) protein, Dumpy, guides the position and direction of buckling-induced folds. Dumpy anchors the wing epithelium to the overlying cuticle at specific tissue positions. Tissue-wide alterations of Dumpy deposition and degradation yielded different buckling patterns. In summary, we propose that spatiotemporal ECM remodeling shapes stereotyped tissue folding through dynamic interactions between the epithelium and its external structures. | en |
dc.language.iso | eng | - |
dc.publisher | American Association for the Advancement of Science (AAAS) | en |
dc.rights | Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). | en |
dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.title | Spatiotemporal remodeling of extracellular matrix orients epithelial sheet folding | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Science Advances | en |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 35 | - |
dc.relation.doi | 10.1126/sciadv.adh2154 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | eadh2154 | - |
dc.address | Graduate School of Biostudies, Kyoto University | en |
dc.address | Department of Biological Sciences, Osaka University; Program of Mathematical and Life Sciences, Hiroshima University | en |
dc.address | Graduate School of Biostudies, Kyoto University; The Keihanshin Consortium for Fostering the Next Generation of Global Leaders in Research (K-CONNEX); Present address: Laboratory for Developmental Genome System, RIKEN Center for Biosystems Dynamics Research | en |
dc.identifier.pmid | 37656799 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2023-09-04 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/en/research-news/2023-09-07 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 19J00764 | - |
datacite.awardNumber | 21H05779 | - |
datacite.awardNumber | 17H06386 | - |
datacite.awardNumber | 16H06280 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19J00764/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21H05779/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-17H06386/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06280/ | - |
dc.identifier.eissn | 2375-2548 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 昆虫の羽化翅に見られる三次元的な折れたたみの形成機構とその意義 | ja |
jpcoar.awardTitle | 細胞外マトリックスを基盤とする昆虫の羽化翅の建築原理の解明 | ja |
jpcoar.awardTitle | 進化のゆらぎ応答理論の確立と多階層・発生過程への展開 | ja |
jpcoar.awardTitle | 先端バイオイメージング支援プラットフォーム | ja |
出現コレクション: | 学術雑誌掲載論文等 |
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス