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タイトル: | Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow |
著者: | Abe, Shinya Asahi, Takuma Hara, Takahiro Cui, Guangwei Shimba, Akihiro Tani-ichi, Shizue Yamada, Kohei Miyazaki, Kazuko Miyachi, Hitoshi Kitano, Satsuki Nakamura, Naotoshi Kikuta, Junichi Vandenbon, Alexis Miyazaki, Masaki Yamada, Ryo Ohteki, Toshiaki Ishii, Masaru Sexl, Veronika Nagasawa, Takashi Ikuta, Koichi https://orcid.org/0000-0003-1319-1021 (unconfirmed) |
著者名の別形: | 阿部, 真也 旭, 拓真 原, 崇裕 崔, 広為 榛葉, 旭恒 谷一, 靖江 山田, 浩平 宮崎, 和子 宮地, 均 北野, さつき 中村, 直俊 菊田, 順一 宮崎, 正輝 山田, 亮 樗木, 俊聡 石井, 優 長澤, 丘司 生田, 宏一 |
キーワード: | bone marrow CXCL12 CXCR4 IL-15 ILC1 innate lymphoid cell microenvironment NK cell NK cell development stromal cell |
発行日: | 26-Sep-2023 |
出版者: | Elsevier BV |
誌名: | Cell Reports |
巻: | 42 |
号: | 9 |
論文番号: | 113127 |
抄録: | Natural killer (NK) cells are innate immune cells critical for protective immune responses against infection and cancer. Although NK cells differentiate in the bone marrow (BM) in an interleukin-15 (IL-15)-dependent manner, the cellular source of IL-15 remains elusive. Using NK cell reporter mice, we show that NK cells are localized in the BM in scattered and clustered manners. NK cell clusters overlap with monocyte and dendritic cell accumulations, whereas scattered NK cells require CXCR4 signaling. Using cell-specific IL-15-deficient mice, we show that hematopoietic cells, but not stromal cells, support NK cell development in the BM through IL-15. In particular, IL-15 produced by monocytes and dendritic cells appears to contribute to NK cell development. These results demonstrate that hematopoietic cells are the IL-15 niche for NK cell development in the BM and that BM NK cells are present in scattered and clustered compartments by different mechanisms, suggesting their distinct functions in the immune response. |
記述: | 骨髄のNK細胞の分化に造血細胞が産生するIL-15が必須である --2種類の局在を示すNK細胞の新規分化モデル--. 京都大学プレスリリース. 2023-09-20. |
著作権等: | © 2023 The Authors. This is an open access article under the CC BY license. |
URI: | http://hdl.handle.net/2433/285242 |
DOI(出版社版): | 10.1016/j.celrep.2023.113127 |
PubMed ID: | 37729919 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2023-09-20 |
出現コレクション: | 学術雑誌掲載論文等 |
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