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Title: The Ethics of Human Brain Organoid Transplantation in Animals
Authors: Kataoka, Masanori
Gyngell, Christopher
Savulescu, Julian
Sawai, Tsutomu
Author's alias: 片岡, 雅知
ギンジェル, クリストファー
サヴァレスキュ, ジュリアン
澤井, 努
Keywords: Brain organoids
Chimeras
Transplantation
Consciousness
Enhancement
Issue Date: Oct-2023
Publisher: Springer Nature
Journal title: Neuroethics
Volume: 16
Issue: 3
Thesis number: 27
Abstract: In this paper, we outline how one might conduct a comprehensive ethical evaluation of human brain organoid transplantation in animals. Thus far, ethical concerns regarding this type of research have been assumed to be similar to those associated with other transplants of human cells in animals, and have therefore not received significant attention. The focus has been only on the welfare, moral status, or mental capacities of the host animal. However, the transplantation of human brain organoids introduces several new ethical issues. Many of these are related to uncertainty regarding whether or not brain organoids might be conscious. While these concerns might not be immediately relevant, they warrant closer scrutiny. We discuss how various ethical issues are relevant to different stages of human brain organoid transplantation and can guide the ethical evaluation of research. Our examination would broaden the horizons of the debate on the transplantation of brain organoids.
Description: ヒト脳組織の動物移植に伴う倫理問題を体系化. 京都大学プレスリリース. 2023-10-19.
Rights: © The Author(s) 2023
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
URI: http://hdl.handle.net/2433/285576
DOI(Published Version): 10.1007/s12152-023-09532-3
PubMed ID: 37809032
Related Link: https://ashbi.kyoto-u.ac.jp/ja/news/20231019_research-result_tsutomu-sawai/
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