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タイトル: | Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila |
著者: | Takakura, Mai Nakagawa, Reiko Ota, Takeshi Kimura, Yoko NG, Man Yung Alia, Abdalla G. Okuno, Hiroyuki Hirano, Yukinori |
著者名の別形: | 平野, 恭敬 |
キーワード: | Acetylation Consolidation Transcription |
発行日: | 27-Jan-2021 |
出版者: | Springer Nature |
誌名: | Nature Communications |
巻: | 12 |
論文番号: | 628 |
抄録: | Consolidated memory can be preserved or updated depending on the environmental change. Although such conflicting regulation may happen during memory updating, the flexibility of memory updating may have already been determined in the initial memory consolidation process. Here, we explored the gating mechanism for activity-dependent transcription in memory consolidation, which is unexpectedly linked to the later memory updating in Drosophila. Through proteomic analysis, we discovered that the compositional change in the transcriptional repressor, which contains the histone deacetylase Rpd3 and CoRest, acts as the gating mechanism that opens and closes the time window for activity-dependent transcription. Opening the gate through the compositional change in Rpd3/CoRest is required for memory consolidation, but closing the gate through Rpd3/CoRest is significant to limit future memory updating. Our data indicate that the flexibility of memory updating is determined through the initial activity-dependent transcription, providing a mechanism involved in defining memory state. |
著作権等: | © The Author(s) 2021 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
URI: | http://hdl.handle.net/2433/285962 |
DOI(出版社版): | 10.1038/s41467-021-20898-x |
PubMed ID: | 33504795 |
出現コレクション: | 学術雑誌掲載論文等 |
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