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タイトル: | 去勢抵抗性前立腺癌に対するドセタキセル療法後の休薬期間に関する検討 |
その他のタイトル: | The Relationship Between Prognosis and Duration of Drug Holidays after Docetaxel Therapy for Castration-Resistant Prostate Cancer |
著者: | 大西, 健太 田中, 宣道 中井, 靖 髙松, 倫己 宮本, 達貴 富澤, 満 清水, 卓斗 堀, 俊太 三宅, 牧人 藤本, 清秀 |
著者名の別形: | ONISHI, Kenta TANAKA, Nobumichi NAKAI, Yasushi TAKAMATSU, Norimi MIYAMOTO, Tatsuki TOMIZAWA, Mitsuru SHIMIZU, Takuto HORI, Shunta MIYAKE, Makito FUJIMOTO, Kiyohide |
キーワード: | Castration-resistant prostate cancer Docetaxel Drug holidays |
発行日: | 31-Oct-2023 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 69 |
号: | 10 |
開始ページ: | 269 |
終了ページ: | 277 |
抄録: | The next treatment strategy after drug holidays following docetaxel (DTX) therapy for patients with castration-resistant prostate cancer (CRPC) is unclear. This study investigated the relationship between the duration of drug holidays and prognosis after DTX therapy. This study retrospectively assessed 26 patients treated with DTX in our hospital. Overall survival duration was significantly longer in the long-term withdrawal group (duration of drug holidays ≥6 months) than in the short-term withdrawal group (duration of drug holidays <6 months) (P=0.015). Similarly, progression-free survival duration was significantly longer in the long-term withdrawal group than in the short-term withdrawal group (P=0.008). The short-term withdrawal group had a significantly lower body mass index (P=0.009) and higher prostate-specific antigen (PSA) (P=0.017) at the initiation of DTX therapy, higher PSA nadir during DTX therapy (P=0.009), and higher PSA at the end of DTX therapy (P=0.022), compared to the long-term withdrawal group. This study suggests that the optimal opportunity to introduce DXT therapy is when the patients with CRPC are physically able to tolerate chemotherapy and their tumor volume remains a lower burden. This may provide a clinical benefit, longer drug holidays, and a better prognosis. |
記述: | 本論文の要旨は,日本泌尿器腫瘍学会第8回学術集会で発表を行った. |
著作権等: | 許諾条件により本文は2024-11-01に公開 |
DOI: | 10.14989/ActaUrolJap_69_10_269 |
URI: | http://hdl.handle.net/2433/285980 |
PubMed ID: | 37914372 |
出現コレクション: | Vol.69 No.10 |
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