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タイトル: 去勢抵抗性前立腺癌に対するドセタキセル療法後の休薬期間に関する検討
その他のタイトル: The Relationship Between Prognosis and Duration of Drug Holidays after Docetaxel Therapy for Castration-Resistant Prostate Cancer
著者: 大西, 健太  KAKEN_name
田中, 宣道  KAKEN_name
中井, 靖  KAKEN_name
髙松, 倫己  KAKEN_name
宮本, 達貴  KAKEN_name
富澤, 満  KAKEN_name
清水, 卓斗  KAKEN_name
堀, 俊太  KAKEN_name
三宅, 牧人  KAKEN_name
藤本, 清秀  KAKEN_name
著者名の別形: ONISHI, Kenta
TANAKA, Nobumichi
NAKAI, Yasushi
TAKAMATSU, Norimi
MIYAMOTO, Tatsuki
TOMIZAWA, Mitsuru
SHIMIZU, Takuto
HORI, Shunta
MIYAKE, Makito
FUJIMOTO, Kiyohide
キーワード: Castration-resistant prostate cancer
Docetaxel
Drug holidays
発行日: 31-Oct-2023
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要
巻: 69
号: 10
開始ページ: 269
終了ページ: 277
抄録: The next treatment strategy after drug holidays following docetaxel (DTX) therapy for patients with castration-resistant prostate cancer (CRPC) is unclear. This study investigated the relationship between the duration of drug holidays and prognosis after DTX therapy. This study retrospectively assessed 26 patients treated with DTX in our hospital. Overall survival duration was significantly longer in the long-term withdrawal group (duration of drug holidays ≥6 months) than in the short-term withdrawal group (duration of drug holidays <6 months) (P=0.015). Similarly, progression-free survival duration was significantly longer in the long-term withdrawal group than in the short-term withdrawal group (P=0.008). The short-term withdrawal group had a significantly lower body mass index (P=0.009) and higher prostate-specific antigen (PSA) (P=0.017) at the initiation of DTX therapy, higher PSA nadir during DTX therapy (P=0.009), and higher PSA at the end of DTX therapy (P=0.022), compared to the long-term withdrawal group. This study suggests that the optimal opportunity to introduce DXT therapy is when the patients with CRPC are physically able to tolerate chemotherapy and their tumor volume remains a lower burden. This may provide a clinical benefit, longer drug holidays, and a better prognosis.
記述: 本論文の要旨は,日本泌尿器腫瘍学会第8回学術集会で発表を行った.
著作権等: 許諾条件により本文は2024-11-01に公開
DOI: 10.14989/ActaUrolJap_69_10_269
URI: http://hdl.handle.net/2433/285980
PubMed ID: 37914372
出現コレクション:Vol.69 No.10

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