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タイトル: | 尿路感染症による敗血症性DICに対する遺伝子組み換えトロンボモジュリンの有効性についての検討 |
その他のタイトル: | Efficacy of Recombinant Thrombomodulin for Sepsis-Associated Disseminated Intravascular Coagulation Caused by Urinary Tract Infections |
著者: | 橘, 進彰 ![]() 飯田, 孝太 ![]() 伊丹, 祥隆 ![]() 橋村, 正哉 ![]() 豊島, 優多 ![]() 細川, 幸成 ![]() 藤本, 清秀 ![]() |
著者名の別形: | TACHIBANA, Akira IIDA, Kota ITAMI, Yoshitaka HASHIMURA, Masaya TOYOSHIMA, Yuta HOSOKAWA, Yukinari FUJIMOTO, Kiyohide |
キーワード: | Disseminated intravascular coagulation Recombinant thrombomodulin Urinary tract infection |
発行日: | 30-Nov-2023 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 69 |
号: | 11 |
開始ページ: | 309 |
終了ページ: | 314 |
抄録: | Severe urinary tract infections occasionally cause sepsis and disseminated intravascular coagulation (DIC). We examined the efficacy of recombinant thrombomodulin (rTM) for treating DIC caused by urosepsis. We enrolled 40 patients who were diagnosed with DIC caused by urosepsis at our hospital between April 2018 and May 2022. Twenty-six patients were treated with rTM (rTM group), while 14 patients did not receive rTM (non-rTM group). The DIC score before treatment in the rTM group was significantly higher than that in the non-rTM group (P<0.01). There was no significant difference in disease-specific survival between the two groups. There was a significant improvement in DIC scores on days 1-3 after administering rTM. However, the duration of DIC in the rTM group was significantly longer than that in the non-rTM group (P=0.038). The administration of rTM may have benefits in patients with DIC caused by urosepsis. |
著作権等: | 許諾条件により本文は2024-12-01に公開 |
DOI: | 10.14989/ActaUrolJap_69_11_309 |
URI: | http://hdl.handle.net/2433/286244 |
PubMed ID: | 38031329 |
出現コレクション: | Vol.69 No.11 |
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