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dc.contributor.author | Lee, Seirin Sungrim | en |
dc.contributor.author | Matsubara, Daiki | en |
dc.contributor.author | Yanase, Yuhki | en |
dc.contributor.author | Kunieda, Takuma | en |
dc.contributor.author | Takahagi, Shunsuke | en |
dc.contributor.author | Hide, Michihiro | en |
dc.contributor.alternative | 李, 聖林 | ja |
dc.contributor.alternative | 松原, 大樹 | ja |
dc.contributor.alternative | 柳瀬, 雄輝 | ja |
dc.contributor.alternative | 國枝, 拓真 | ja |
dc.contributor.alternative | 高萩, 俊輔 | ja |
dc.contributor.alternative | 秀, 道広 | ja |
dc.date.accessioned | 2023-12-07T07:38:09Z | - |
dc.date.available | 2023-12-07T07:38:09Z | - |
dc.date.issued | 2023-12-04 | - |
dc.identifier.uri | http://hdl.handle.net/2433/286318 | - |
dc.description | 発疹の形状から蕁麻疹の体内メカニズムを解き明かす数理皮膚医学を創出 --数理モデルと臨床医学の融合による新たな蕁麻疹治療法の開発へ--. 京都大学プレスリリース. 2023-12-05. | ja |
dc.description | Unravelling the mechanism of urticaria from eruption shapes: Innovation for developing new treatments based on eruption morphology in mathematical dermatology. 京都大学プレスリリース. 2023-12-05. | en |
dc.description.abstract | [Background] Chronic spontaneous urticaria (CSU) is one of the most intractable human-specific skin diseases. However, as no experimental animal model exists, the mechanism underlying disease pathogenesis in vivo remains unclear, making the establishment of a curative treatment challenging. [Methods] A novel approach combining mathematical modelling, in vitro experiments and clinical data analysis was used to infer the pathological state of CSU patients from geometric features of the skin eruptions. [Results] Based on our hierarchical mathematical modelling, the eruptions of CSU were classified into five categories, each with distinct histamine, basophils, mast cells and coagulation factors network signatures. The analysis of 105 real CSU patients with this classification by six individual dermatologists achieved 87.6% agreement. Furthermore, our network analysis revealed that the coagulation status likely determines boundary/area pattern of wheals, while the state of spontaneous histamine release from mast cells may contribute to the divergence of size and outline of the eruptions. [Conclusions] Our multi-faceted approach was accurate in defining pathophysiological states of disease based on geometric features offering the potential to improve the accuracy of CSU diagnosis and better management of the disease in the clinic. | en |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | © The Author(s) 2023 | en |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Autoimmune diseases | en |
dc.subject | Skin diseases | en |
dc.title | Mathematical-based morphological classification of skin eruptions corresponding to the pathophysiological state of chronic spontaneous urticaria | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Communications Medicine | en |
dc.identifier.volume | 3 | - |
dc.relation.doi | 10.1038/s43856-023-00404-8 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 171 | - |
dc.address | Kyoto University Institute for the Advanced Study of Human Biology (ASHBi), KUIAS, Kyoto University; Department of Mathematical Medicine, Graduate School of Medicine, Kyoto University; JST CREST | en |
dc.address | Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University | en |
dc.address | JST CREST; Department of Pharmacotherapy, Graduate School of Biomedical Sciences, Hiroshima University | en |
dc.address | Department of Pharmacotherapy, Graduate School of Biomedical Sciences, Hiroshima University | en |
dc.address | JST CREST; Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University | en |
dc.address | Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University; Department of Dermatology, Hiroshima City Hiroshima Citizens Hospital | en |
dc.identifier.pmid | 38049619 | - |
dc.relation.url | https://ashbi.kyoto-u.ac.jp/ja/news/20231205_research-result_seirin-lee/ | - |
dc.relation.url | https://ashbi.kyoto-u.ac.jp/news/20231205_research-result_seirin-lee/ | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 21K08301 | - |
datacite.awardNumber | 21K08346 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08301/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08346/ | - |
dc.identifier.eissn | 2730-664X | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 慢性蕁麻疹の病態における血液凝固系・補体系の役割解明と診断・治療標的の探索 | ja |
jpcoar.awardTitle | コリン性蕁麻疹における汗アレルギー発症とマスト細胞活性化機序の解明 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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