ダウンロード数: 33
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
jmp.12642.pdf | 8.44 MB | Adobe PDF | 見る/開く |
タイトル: | Hypercholesterolemia induced by spontaneous oligogenic mutations in rhesus macaques (Macaca mulatta) |
著者: | Takenaka, Akiko Suzuki, Juri Tanaka, Hiroyuki Hibino, Kumiko Kamanaka, Yoshiro Nakamura, Shin Mitsunaga, Fusako Kawamoto, Yoshi Morimoto, Mayumi Aisu, Seitaro Natsume, Takayoshi |
著者名の別形: | 鈴木, 樹理 田中, 洋之 釜中, 慶朗 川本, 芳 森本, 真弓 愛洲, 星太郎 夏目, 尊好 |
キーワード: | activity of LDLR cholesterol hemizygote LDLR MBTPS2 model animal mRNA S2P sex- linked inheritance and recessive inheritance |
発行日: | Aug-2023 |
出版者: | Wiley |
誌名: | Journal of Medical Primatology |
巻: | 52 |
号: | 4 |
開始ページ: | 230 |
終了ページ: | 243 |
抄録: | [Background] A rhesus macaque with the fourth highest plasma cholesterol (CH) levels of 501 breeding macaques was identified 22 years ago. Seven offspring with gene mutations causing hypercholesterolemia were obtained. [Methods] Activity of low-density lipoprotein receptor (LDLR), plasma CH levels and mRNA expression levels of LDLR were measured after administration of 0.1% (0.27 mg/kcal) or 0.3% CH. [Results] Activity of p. (Cys82Tyr) of LDLR was 71% and 42% in the heterozygotes and a homozygote, respectively. The mRNA expression level of LDLR in the p. (Val241Ile) of membrane-bound transcription factor protease, site 2 (MBTPS2, S2P protein) was 0.83 times lower than normal levels. LDLR mRNA levels were increased for up to 4 weeks by administration of 0.3% CH before suddenly decreasing to 80% of the baseline levels after 6 weeks. [Conclusion] Oligogenic mutations of p. (Cys82Tyr) in LDLR and p. (Val241Ile) in MBTPS2 (S2P) caused hypercholesterolemia exceeding cardiovascular risk levels under a 0.1% CH diet. |
著作権等: | © 2023 The Authors. Journal of Medical Primatology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
URI: | http://hdl.handle.net/2433/286389 |
DOI(出版社版): | 10.1111/jmp.12642 |
PubMed ID: | 37186395 |
出現コレクション: | 学術雑誌掲載論文等 |
このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス