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DCフィールド | 値 | 言語 |
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dc.contributor.author | Miyamoto, Sho | en |
dc.contributor.author | Nishiyama, Takara | en |
dc.contributor.author | Ueno, Akira | en |
dc.contributor.author | Park, Hyeongki | en |
dc.contributor.author | Kanno, Takayuki | en |
dc.contributor.author | Nakamura, Naotoshi | en |
dc.contributor.author | Ozono, Seiya | en |
dc.contributor.author | Aihara, Kazuyuki | en |
dc.contributor.author | Takahashi, Kenichiro | en |
dc.contributor.author | Tsuchihashi, Yuuki | en |
dc.contributor.author | Ishikane, Masahiro | en |
dc.contributor.author | Arashiro, Takeshi | en |
dc.contributor.author | Saito, Shinji | en |
dc.contributor.author | Ainai, Akira | en |
dc.contributor.author | Hirata, Yuichiro | en |
dc.contributor.author | Iida, Shun | en |
dc.contributor.author | Katano, Harutaka | en |
dc.contributor.author | Tobiume, Minoru | en |
dc.contributor.author | Tokunaga, Kenzo | en |
dc.contributor.author | Fujimoto, Tsuguto | en |
dc.contributor.author | Suzuki, Michiyo | en |
dc.contributor.author | Nagashima, Maki | en |
dc.contributor.author | Nakagawa, Hidenori | en |
dc.contributor.author | Narita, Masashi | en |
dc.contributor.author | Kato, Yasuyuki | en |
dc.contributor.author | Igari, Hidetoshi | en |
dc.contributor.author | Fujita, Kaori | en |
dc.contributor.author | Kato, Tatsuo | en |
dc.contributor.author | Hiyama, Kazutoshi | en |
dc.contributor.author | Shindou, Keisuke | en |
dc.contributor.author | Adachi, Takuya | en |
dc.contributor.author | Fukushima, Kazuaki | en |
dc.contributor.author | Nakamura-Uchiyama, Fukumi | en |
dc.contributor.author | Hase, Ryota | en |
dc.contributor.author | Yoshimura, Yukihiro | en |
dc.contributor.author | Yamato, Masaya | en |
dc.contributor.author | Nozaki, Yasuhiro | en |
dc.contributor.author | Ohmagari, Norio | en |
dc.contributor.author | Suzuki, Motoi | en |
dc.contributor.author | Saito, Tomoya | en |
dc.contributor.author | Iwami, Shingo | en |
dc.contributor.author | Suzuki, Tadaki | en |
dc.contributor.alternative | 宮本, 翔 | ja |
dc.contributor.alternative | 西山, 尚来 | ja |
dc.contributor.alternative | 上野, 朗 | ja |
dc.contributor.alternative | 菅野, 隆行 | ja |
dc.contributor.alternative | 中村, 直俊 | ja |
dc.contributor.alternative | 大園, 誠也 | ja |
dc.contributor.alternative | 合原, 一幸 | ja |
dc.contributor.alternative | 高橋, 健一郎 | ja |
dc.contributor.alternative | 土橋, 酉紀 | ja |
dc.contributor.alternative | 石金, 正裕 | ja |
dc.contributor.alternative | 新城, 雄士 | ja |
dc.contributor.alternative | 齊藤, 慎二 | ja |
dc.contributor.alternative | 相内, 章 | ja |
dc.contributor.alternative | 平田, 雄一郎 | ja |
dc.contributor.alternative | 飯田, 俊 | ja |
dc.contributor.alternative | 片野, 晴隆 | ja |
dc.contributor.alternative | 飛梅, 実 | ja |
dc.contributor.alternative | 徳永, 研三 | ja |
dc.contributor.alternative | 藤本, 嗣人 | ja |
dc.contributor.alternative | 長島, 麻希 | ja |
dc.contributor.alternative | 中河, 秀憲 | ja |
dc.contributor.alternative | 成田, 雅 | ja |
dc.contributor.alternative | 加藤, 康幸 | ja |
dc.contributor.alternative | 猪狩, 英俊 | ja |
dc.contributor.alternative | 藤田, 香織 | ja |
dc.contributor.alternative | 加藤, 達雄 | ja |
dc.contributor.alternative | 肥山, 和俊 | ja |
dc.contributor.alternative | 進藤, 圭介 | ja |
dc.contributor.alternative | 足立, 拓也 | ja |
dc.contributor.alternative | 福島, 一彰 | ja |
dc.contributor.alternative | 中村, ふくみ | ja |
dc.contributor.alternative | 馳, 亮太 | ja |
dc.contributor.alternative | 吉村, 幸浩 | ja |
dc.contributor.alternative | 倭, 正也 | ja |
dc.contributor.alternative | 野崎, 裕広 | ja |
dc.contributor.alternative | 大曲, 貴夫 | ja |
dc.contributor.alternative | 鈴木, 基 | ja |
dc.contributor.alternative | 齋藤, 智也 | ja |
dc.contributor.alternative | 岩見, 真吾 | ja |
dc.contributor.alternative | 鈴木, 忠樹 | ja |
dc.date.accessioned | 2024-01-04T07:10:09Z | - |
dc.date.available | 2024-01-04T07:10:09Z | - |
dc.date.issued | 2023-12-26 | - |
dc.identifier.uri | http://hdl.handle.net/2433/286523 | - |
dc.description | 新型コロナウイルス排出と粘膜抗体の関係を解明 --呼吸器ウイルスのヒト間伝播を制御・予防する第一歩--. 京都大学プレスリリース. 2023-12-25. | ja |
dc.description | Articles: Infectious virus shedding duration reflects secretory IgA antibody response latency after SARS-CoV-2 infection. 京都大学プレスリリース. 2023-12-25. | en |
dc.description.abstract | Infectious virus shedding from individuals infected with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is used to estimate human-to-human transmission risk. Control of SARS-CoV-2 transmission requires identifying the immune correlates that protect infectious virus shedding. Mucosal immunity prevents infection by SARS-CoV-2, which replicates in the respiratory epithelium and spreads rapidly to other hosts. However, whether mucosal immunity prevents the shedding of the infectious virus in SARS-CoV-2-infected individuals is unknown. We examined the relationship between viral RNA shedding dynamics, duration of infectious virus shedding, and mucosal antibody responses during SARS-CoV-2 infection. Anti-spike secretory IgA antibodies (S-IgA) reduced viral RNA load and infectivity more than anti-spike IgG/IgA antibodies in infected nasopharyngeal samples. Compared with the IgG/IgA response, the anti-spike S-IgA post-infection responses affected the viral RNA shedding dynamics and predicted the duration of infectious virus shedding regardless of the immune history. These findings highlight the importance of anti-spike S-IgA responses in individuals infected with SARS-CoV-2 for preventing infectious virus shedding and SARS-CoV-2 transmission. Developing medical countermeasures to shorten S-IgA response time may help control human-to-human transmission of SARS-CoV-2 infection and prevent future respiratory virus pandemics. | en |
dc.language.iso | eng | - |
dc.publisher | National Academy of Sciences | en |
dc.rights | Copyright © 2023 the Author(s). Published by PNAS. | en |
dc.rights | This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY). | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | MUCOSAL SECRETORY IGA | en |
dc.subject | INFECTIOUS VIRUS SHEDDING DURATION | en |
dc.subject | HUMAN-TO-HUMAN TRANSMISSION | en |
dc.subject | COVID-19 VACCINE | en |
dc.subject | PRIOR-INFECTION | en |
dc.title | Infectious virus shedding duration reflects secretory IgA antibody response latency after SARS-CoV-2 infection | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Proceedings of the National Academy of Sciences of the United States of America | en |
dc.identifier.volume | 120 | - |
dc.identifier.issue | 52 | - |
dc.relation.doi | 10.1073/pnas.2314808120 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | e2314808120 | - |
dc.address | Department of Pathology, National Institute of Infectious Diseases | en |
dc.address | Interdisciplinary Biology Laboratory, Division of Natural Science, Graduate School of Science, Nagoya University | en |
dc.address | Department of Pathology, National Institute of Infectious Diseases | en |
dc.address | Interdisciplinary Biology Laboratory, Division of Natural Science, Graduate School of Science, Nagoya University | en |
dc.address | Department of Pathology, National Institute of Infectious Diseases | en |
dc.address | Interdisciplinary Biology Laboratory, Division of Natural Science, Graduate School of Science, Nagoya University | en |
dc.address | Department of Pathology, National Institute of Infectious Diseases | en |
dc.address | International Research Center for Neurointelligence, The University of Tokyo Institutes for Advanced Study, The University of Tokyo | en |
dc.address | Center for Emergency Preparedness and Response, National Institute of Infectious Diseases | en |
dc.address | Center for surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases; Center for Field Epidemic Intelligence, Research and Professional Development, National Institute of Infectious Diseases | en |
dc.address | Disease Control and Prevention Center, National Center for Global Health and Medicine | en |
dc.address | Department of Pathology, National Institute of Infectious Diseases; Center for surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases | en |
dc.address | Department of Pathology, National Institute of Infectious Diseases | en |
dc.address | Department of Pathology, National Institute of Infectious Diseases | en |
dc.address | Department of Pathology, National Institute of Infectious Diseases | en |
dc.address | Department of Pathology, National Institute of Infectious Diseases | en |
dc.address | Department of Pathology, National Institute of Infectious Diseases | en |
dc.address | Department of Pathology, National Institute of Infectious Diseases | en |
dc.address | Department of Pathology, National Institute of Infectious Diseases | en |
dc.address | Center for Emergency Preparedness and Response, National Institute of Infectious Diseases | en |
dc.address | Disease Control and Prevention Center, National Center for Global Health and Medicine | en |
dc.address | Disease Control and Prevention Center, National Center for Global Health and Medicine | en |
dc.address | Department of Infectious Diseases, Osaka City General Hospital | en |
dc.address | Division of Infectious Diseases, Department of Internal Medicine, Okinawa Prefectural Nanbu Medical Center and Children's Medical Center | en |
dc.address | Department of Infectious Diseases, International University of Health and Welfare Narita Hospital | en |
dc.address | Department of Infection Control, Chiba University Hospital | en |
dc.address | Department of Respiratory Medicine, National Hospital Organization Okinawa National Hospital | en |
dc.address | Department of Chest Disease, National Hospital Organization Nagara Medical Center | en |
dc.address | Department of Infectious Disease, National Hospital Organization Fukuoka- Higashi Medical Center | en |
dc.address | Department of Pediatrics, Hirakata City Hospital | en |
dc.address | Department of Infectious Diseases, Tokyo Metropolitan Toshima Hospital | en |
dc.address | Department of Infectious Disease, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital | en |
dc.address | Department of Infectious Diseases, Tokyo Metropolitan Bokutoh Hospital | en |
dc.address | Department of Infectious Diseases, Japanese Red Cross Narita Hospital | en |
dc.address | Division of Infectious Disease, Yokohama Municipal Citizen's Hospital | en |
dc.address | Department of General Internal Medicine and Infectious Diseases, Rinku General Medical Center | en |
dc.address | Department of Respiratory Medicine, Tokoname City Hospital | en |
dc.address | Disease Control and Prevention Center, National Center for Global Health and Medicine | en |
dc.address | Center for surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases | en |
dc.address | Center for Emergency Preparedness and Response, National Institute of Infectious Diseases | en |
dc.address | Interdisciplinary Biology Laboratory, Division of Natural Science, Graduate School of Science, Nagoya University; Institute of Mathematics for Industry, Kyushu University; Institute for the Advanced Study of Human Biology, Kyoto University; Interdisciplinary Theoretical and Mathematical Sciences Program, RIKEN: NEXT- Ganken Program, Japanese Foundation for Cancer Research; Science Groove Inc. | en |
dc.address | Department of Pathology, National Institute of Infectious Diseases | en |
dc.identifier.pmid | 38134196 | - |
dc.relation.url | https://ashbi.kyoto-u.ac.jp/ja/news/20231219_research-result_shingo-iwami/ | - |
dc.relation.url | https://ashbi.kyoto-u.ac.jp/news/20231219_research-result_shingo-iwami/ | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 18H01139 | - |
datacite.awardNumber | 20H03500 | - |
datacite.awardNumber | 23H02731 | - |
datacite.awardNumber | 21K20768 | - |
datacite.awardNumber | 23K14534 | - |
datacite.awardNumber | 23KJ1081 | - |
datacite.awardNumber | 20H05042 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H01139/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03500/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02731/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K20768/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K14534/ | - |
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datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-20H05042/ | - |
dc.identifier.pissn | 0027-8424 | - |
dc.identifier.eissn | 1091-6490 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 生命科学におけるパターン形成の新しいモデルと数学的解析手法の確立 | ja |
jpcoar.awardTitle | 四量体分泌型IgA抗体を用いた抗ウイルス抗体医薬開発のための基盤研究 | ja |
jpcoar.awardTitle | 抗ウイルス活性を有する多重特異性四量体分泌型IgA抗体の形成制御機構の解明 | ja |
jpcoar.awardTitle | SFTSウイルスによる免疫細胞間伝播機構の描出 | ja |
jpcoar.awardTitle | SFTSウイルスのB細胞内侵入・増殖戦略の解明 | ja |
jpcoar.awardTitle | 細胞機能を利用する病原体の内在化動態の定量的理解 | ja |
jpcoar.awardTitle | 造血幹細胞老化により変容する細胞ダイバーシティの数理科学的解析 | ja |
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