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dc.contributor.author | Nishiyama, Akihito | en |
dc.contributor.author | Shimizu, Masahiro | en |
dc.contributor.author | Narita, Tomoyuki | en |
dc.contributor.author | Kodera, Noriyuki | en |
dc.contributor.author | Ozeki, Yuriko | en |
dc.contributor.author | Yokoyama, Akira | en |
dc.contributor.author | Mayanagi, Kouta | en |
dc.contributor.author | Yamaguchi, Takehiro | en |
dc.contributor.author | Hakamata, Mariko | en |
dc.contributor.author | Shaban, Amina Kaboso | en |
dc.contributor.author | Tateishi, Yoshitaka | en |
dc.contributor.author | Ito, Kosuke | en |
dc.contributor.author | Matsumoto, Sohkichi | en |
dc.contributor.alternative | 西山, 晃史 | ja |
dc.contributor.alternative | 清水, 将裕 | ja |
dc.contributor.alternative | 成田, 知恕 | ja |
dc.contributor.alternative | 古寺, 哲幸 | ja |
dc.contributor.alternative | 尾関, 百合子 | ja |
dc.contributor.alternative | 横山, 晃 | ja |
dc.contributor.alternative | 眞栁, 浩太 | ja |
dc.contributor.alternative | 山口, 雄大 | ja |
dc.contributor.alternative | 袴田, 真理子 | ja |
dc.contributor.alternative | 立石, 善隆 | ja |
dc.contributor.alternative | 伊東, 孝祐 | ja |
dc.contributor.alternative | 松本, 壮吉 | ja |
dc.date.accessioned | 2024-02-16T02:53:12Z | - |
dc.date.available | 2024-02-16T02:53:12Z | - |
dc.date.issued | 2024-01-25 | - |
dc.identifier.uri | http://hdl.handle.net/2433/287026 | - |
dc.description | 抗酸菌における決定的な休眠誘導機構を発見 --天然変性タンパク質による新規のDNA凝集メカニズム--. 京都大学プレスリリース. 2024-02-14. | ja |
dc.description.abstract | Mycobacteria are the major human pathogens with the capacity to become dormant persisters. Mycobacterial DNA-binding protein 1 (MDP1), an abundant histone-like protein in dormant mycobacteria, induces dormancy phenotypes, e.g. chromosome compaction and growth suppression. For these functions, the polycationic intrinsically disordered region (IDR) is essential. However, the disordered property of IDR stands in the way of clarifying the molecular mechanism. Here we clarified the molecular and structural mechanism of DNA compaction by MDP1. Using high-speed atomic force microscopy, we observed that monomeric MDP1 bundles two adjacent DNA duplexes side-by-side via IDR. Combined with coarse-grained molecular dynamics simulation, we revealed the novel dynamic DNA cross-linking model of MDP1 in which a stretched IDR cross-links two DNA duplexes like double-sided tape. IDR is able to hijack HU function, resulting in the induction of strong mycobacterial growth arrest. This IDR-mediated reversible DNA cross-linking is a reasonable model for MDP1 suppression of the genomic function in the resuscitable non-replicating dormant mycobacteria. | en |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press (OUP) | en |
dc.rights | © The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research. | en |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.title | Dynamic action of an intrinsically disordered protein in DNA compaction that induces mycobacterial dormancy | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Nucleic Acids Research | en |
dc.identifier.volume | 52 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 816 | - |
dc.identifier.epage | 830 | - |
dc.relation.doi | 10.1093/nar/gkad1149 | - |
dc.textversion | publisher | - |
dc.address | Department of Bacteriology, Niigata University School of Medicine | en |
dc.address | Nano Life Science Institute, Kanazawa University; Division of Quantum Beam Material Science, Institute for Integrated Radiation and Nuclear Science, Kyoto University | en |
dc.address | Nano Life Science Institute, Kanazawa University | en |
dc.address | Nano Life Science Institute, Kanazawa University | en |
dc.address | Department of Bacteriology, Niigata University School of Medicine | en |
dc.address | Department of Bacteriology, Niigata University School of Medicine; Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo | en |
dc.address | Medical Institute of Bioregulation, Kyushu University | en |
dc.address | Department of Bacteriology, Niigata University School of Medicine; Department of Pharmacology, Osaka Metropolitan University Graduate School of Medicine | en |
dc.address | Department of Bacteriology, Niigata University School of Medicine; Department of Respiratory Medicine and Infectious Disease, Niigata University School of Medicine | en |
dc.address | Department of Bacteriology, Niigata University School of Medicine | en |
dc.address | Department of Bacteriology, Niigata University School of Medicine | en |
dc.address | Graduate School of Science and Technology, Niigata University | en |
dc.address | Department of Bacteriology, Niigata University School of Medicine; Laboratory of Tuberculosis, Institute of Tropical Disease, Universitas Airlangga; Division of Research Aids, Hokkaido University Institute for Vaccine Research & Development | en |
dc.identifier.pmid | 38048321 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/ja/research-news/2024-02-14-0 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 17K08823 | - |
datacite.awardNumber | 20H03483 | - |
datacite.awardNumber | 20K22629 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08823/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03483/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K22629/ | - |
dc.identifier.pissn | 0305-1048 | - |
dc.identifier.eissn | 1362-4962 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 細菌における天然変性蛋白質のヒストンコード機構による形質制御の証明 | ja |
jpcoar.awardTitle | 天然変性ヒストン様蛋白質による、結核菌の個性の創出と多様性獲得の分子機構 | ja |
jpcoar.awardTitle | マルチドメイン蛋白質CCSの緻密に設計されたドメイン運動とその物理的起源の研究 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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