Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

Tamura, Tomokazu; Irie, Takashi; Deguchi, Sayaka; Yajima, Hisano; Tsuda, Masumi; Nasser, Hesham; Mizuma, Keita; Plianchaisuk, Arnon; Suzuki, Saori; Uriu, Keiya; Begum, Mst Monira; Shimizu, Ryo; Jonathan, Michael; Suzuki, Rigel; Kondo, Takashi; Ito, Hayato; Kamiyama, Akifumi; Yoshimatsu, Kumiko; Shofa, Maya; Hashimoto, Rina; Anraku, Yuki; Kimura, Kanako Terakado; Kita, Shunsuke; Sasaki, Jiei; Sasaki-Tabata, Kaori; Maenaka, Katsumi; Nao, Naganori; Wang, Lei; Oda, Yoshitaka; The Genotype to Phenotype Japan (G2P-Japan) Consortium; Ikeda, Terumasa; Saito, Akatsuki; Matsuno, Keita; Ito, Jumpei; Tanaka, Shinya; Sato, Kei; Hashiguchi, Takao; Takayama, Kazuo; Fukuhara, Takasuke

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http://hdl.handle.net/2433/287044

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DCフィールド	値	言語
dc.contributor.author	Tamura, Tomokazu	en
dc.contributor.author	Irie, Takashi	en
dc.contributor.author	Deguchi, Sayaka	en
dc.contributor.author	Yajima, Hisano	en
dc.contributor.author	Tsuda, Masumi	en
dc.contributor.author	Nasser, Hesham	en
dc.contributor.author	Mizuma, Keita	en
dc.contributor.author	Plianchaisuk, Arnon	en
dc.contributor.author	Suzuki, Saori	en
dc.contributor.author	Uriu, Keiya	en
dc.contributor.author	Begum, Mst Monira	en
dc.contributor.author	Shimizu, Ryo	en
dc.contributor.author	Jonathan, Michael	en
dc.contributor.author	Suzuki, Rigel	en
dc.contributor.author	Kondo, Takashi	en
dc.contributor.author	Ito, Hayato	en
dc.contributor.author	Kamiyama, Akifumi	en
dc.contributor.author	Yoshimatsu, Kumiko	en
dc.contributor.author	Shofa, Maya	en
dc.contributor.author	Hashimoto, Rina	en
dc.contributor.author	Anraku, Yuki	en
dc.contributor.author	Kimura, Kanako Terakado	en
dc.contributor.author	Kita, Shunsuke	en
dc.contributor.author	Sasaki, Jiei	en
dc.contributor.author	Sasaki-Tabata, Kaori	en
dc.contributor.author	Maenaka, Katsumi	en
dc.contributor.author	Nao, Naganori	en
dc.contributor.author	Wang, Lei	en
dc.contributor.author	Oda, Yoshitaka	en
dc.contributor.author	The Genotype to Phenotype Japan (G2P-Japan) Consortium	en
dc.contributor.author	Ikeda, Terumasa	en
dc.contributor.author	Saito, Akatsuki	en
dc.contributor.author	Matsuno, Keita	en
dc.contributor.author	Ito, Jumpei	en
dc.contributor.author	Tanaka, Shinya	en
dc.contributor.author	Sato, Kei	en
dc.contributor.author	Hashiguchi, Takao	en
dc.contributor.author	Takayama, Kazuo	en
dc.contributor.author	Fukuhara, Takasuke	en
dc.contributor.alternative	田村, 友和	ja
dc.contributor.alternative	入江, 崇	ja
dc.contributor.alternative	出口, 清香	ja
dc.contributor.alternative	矢島, 久乃	ja
dc.contributor.alternative	津田, 真寿美	ja
dc.contributor.alternative	水間, 奎太	ja
dc.contributor.alternative	鈴木, 紗織	ja
dc.contributor.alternative	瓜生, 慧也	ja
dc.contributor.alternative	清水, 凌	ja
dc.contributor.alternative	鈴木, 理滋	ja
dc.contributor.alternative	近藤, 隆	ja
dc.contributor.alternative	伊藤, 駿	ja
dc.contributor.alternative	上山, 晟史	ja
dc.contributor.alternative	吉松, 組子	ja
dc.contributor.alternative	橋本, 里菜	ja
dc.contributor.alternative	安楽, 佑樹	ja
dc.contributor.alternative	木村, 香菜子	ja
dc.contributor.alternative	喜多, 俊介	ja
dc.contributor.alternative	佐々木, 慈英	ja
dc.contributor.alternative	田畑, 香織	ja
dc.contributor.alternative	前仲, 勝実	ja
dc.contributor.alternative	直, 亨則	ja
dc.contributor.alternative	王, 磊	ja
dc.contributor.alternative	小田, 義崇	ja
dc.contributor.alternative	池田, 輝政	ja
dc.contributor.alternative	齊藤, 暁	ja
dc.contributor.alternative	松野, 啓太	ja
dc.contributor.alternative	伊東, 潤平	ja
dc.contributor.alternative	田中, 伸哉	ja
dc.contributor.alternative	佐藤, 佳	ja
dc.contributor.alternative	橋口, 隆生	ja
dc.contributor.alternative	高山, 和雄	ja
dc.contributor.alternative	福原, 崇介	ja
dc.date.accessioned	2024-02-19T09:06:46Z	-
dc.date.available	2024-02-19T09:06:46Z	-
dc.date.issued	2024-02-08	-
dc.identifier.uri	http://hdl.handle.net/2433/287044	-
dc.description	オミクロンXBB.1.5のウイルス学的特性の解明 --新型コロナウイルスの生態の全容解明に貢献すると期待--. 京都大学プレスリリース. 2024-02-16.	ja
dc.description	Combining expertise to characterize the SARS-CoV-2 Omicron XBB.1.5 variant. 京都大学プレスリリース. 2024-02-19.	en
dc.description.abstract	Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB.1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB.1.5 evolved from XBB.1 by acquiring the S486P spike (S) mutation, subsequent to the acquisition of a nonsense mutation in ORF8. Neutralization assays showed similar abilities of immune escape between XBB.1.5 and XBB.1. We determine the structural basis for the interaction between human ACE2 and the S protein of XBB.1.5, showing similar overall structures between the S proteins of XBB.1 and XBB.1.5. We provide the intrinsic pathogenicity of XBB.1 and XBB.1.5 in hamsters. Importantly, we find that the ORF8 nonsense mutation of XBB.1.5 resulted in impairment of MHC suppression. In vivo experiments using recombinant viruses reveal that the XBB.1.5 mutations are involved with reduced virulence of XBB.1.5. Together, our study identifies the two viral functions defined the difference between XBB.1 and XBB.1.5.	en
dc.language.iso	eng	-
dc.publisher	Springer Nature	en
dc.rights	© The Author(s) 2024	en
dc.rights	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	-
dc.subject	Cryoelectron microscopy	en
dc.subject	SARS-CoV-2	en
dc.subject	Virus–host interactions	en
dc.title	Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant	en
dc.type	journal article	-
dc.type.niitype	Journal Article	-
dc.identifier.jtitle	Nature Communications	en
dc.identifier.volume	15	-
dc.relation.doi	10.1038/s41467-024-45274-3	-
dc.textversion	publisher	-
dc.identifier.artnum	1176	-
dc.address	Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University; Graduate School of Medicine, Hokkaido University; School of Medicine, Hokkaido University; Institute for the Advancement of Higher Education, Hokkaido University; Institute for Vaccine Research and Development (IVReD), Hokkaido University; One Health Research Center, Hokkaido University	en
dc.address	Graduate School of Biomedical and Health Sciences, Hiroshima University	en
dc.address	Center for iPS Cell Research and Application (CiRA), Kyoto University	en
dc.address	Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University	en
dc.address	Department of Cancer Pathology, Faculty of Medicine, Hokkaido University; Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University	en
dc.address	Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University; Department of Clinical Pathology, Faculty of Medicine, Suez Canal University	en
dc.address	Division of Risk Analysis and Management, International Institute for Zoonosis Control, Hokkaido University	en
dc.address	Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo	en
dc.address	Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University; Graduate School of Medicine, Hokkaido University; School of Medicine, Hokkaido University; Institute for Vaccine Research and Development (IVReD), Hokkaido University	en
dc.address	Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo; Graduate School of Medicine, The University of Tokyo	en
dc.address	Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University	en
dc.address	Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University	en
dc.address	Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University	en
dc.address	Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University; Graduate School of Medicine, Hokkaido University; School of Medicine, Hokkaido University; Institute for Vaccine Research and Development (IVReD), Hokkaido University	en
dc.address	School of Medicine, Hokkaido University	en
dc.address	Graduate School of Medicine, Hokkaido University	en
dc.address	Graduate School of Medicine, Hokkaido University	en
dc.address	Institute for Genetic Medicine, Hokkaido University	en
dc.address	Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki	en
dc.address	Center for iPS Cell Research and Application (CiRA), Kyoto University	en
dc.address	Laboratory of Biomolecular Science and Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University	en
dc.address	Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University	en
dc.address	Laboratory of Biomolecular Science and Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University	en
dc.address	Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University	en
dc.address	Department of Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University	en
dc.address	One Health Research Center, Hokkaido University; Laboratory of Biomolecular Science and Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University; Division of Pathogen Structure, International Institute for Zoonosis Control, Hokkaido University; Global Station for Biosurfaces and Drug Discovery, Hokkaido University	en
dc.address	Institute for Vaccine Research and Development (IVReD), Hokkaido University; One Health Research Center, Hokkaido University; Division of International Research Promotion, International Institute for Zoonosis Control, Hokkaido University	en
dc.address	Department of Cancer Pathology, Faculty of Medicine, Hokkaido University; Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University	en
dc.address	Department of Cancer Pathology, Faculty of Medicine, Hokkaido University	en
dc.address	Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus Infection, Kumamoto University	en
dc.address	Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki; Center for Animal Disease Control, University of Miyazaki	en
dc.address	Institute for Vaccine Research and Development (IVReD), Hokkaido University; One Health Research Center, Hokkaido University; Division of Risk Analysis and Management, International Institute for Zoonosis Control, Hokkaido University; International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University	en
dc.address	Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo; International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo	en
dc.address	Department of Cancer Pathology, Faculty of Medicine, Hokkaido University; Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University	en
dc.address	Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo; Graduate School of Medicine, The University of Tokyo; International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo; Graduate School of Frontier Sciences, The University of Tokyo; CREST, Japan Science and Technology Agency; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo; Collaboration Unit for Infection, Joint Research Center for Human Retrovirus Infection, Kumamoto University	en
dc.address	Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University; Graduate School of Frontier Sciences, The University of Tokyo; Kyoto University Immunomonitoring Center, Kyoto University	en
dc.address	Center for iPS Cell Research and Application (CiRA), Kyoto University; AMED-CREST, Japan Agency for Medical Research and Development (AMED)	en
dc.address	Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University; Graduate School of Medicine, Hokkaido University; School of Medicine, Hokkaido University; Institute for the Advancement of Higher Education, Hokkaido University; Institute for Vaccine Research and Development (IVReD), Hokkaido University; One Health Research Center, Hokkaido University; Kyoto University Immunomonitoring Center, Kyoto University; Laboratory of Virus Control, Research Institute for Microbial Diseases, Osaka University	en
dc.identifier.pmid	38332154	-
dc.relation.url	https://www.kyoto-u.ac.jp/ja/research-news/2024-02-16-1	-
dc.relation.url	https://www.cira.kyoto-u.ac.jp/j/pressrelease/news/240219-130000.html	-
dc.relation.url	https://www.cira.kyoto-u.ac.jp/e/pressrelease/news/240219-130000.html	-
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jpcoar.awardTitle	内在性レトロウイルスが駆動する遺伝子発現制御ネットワークの生理機能の解明	ja
jpcoar.awardTitle	ウイルスのPLAMP生成機構とPLAMPを介した病原性制御機構の解明	ja
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