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dc.contributor.author | Diez, Antoine | en |
dc.contributor.author | Krause, Andrew L. | en |
dc.contributor.author | Maini, Philip K. | en |
dc.contributor.author | Gaffney, Eamonn A. | en |
dc.contributor.author | Seirin-Lee, Sungrim | en |
dc.contributor.alternative | 李, 聖林 | ja |
dc.date.accessioned | 2024-02-29T01:39:45Z | - |
dc.date.available | 2024-02-29T01:39:45Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.uri | http://hdl.handle.net/2433/287127 | - |
dc.description.abstract | Conditions for self-organisation via Turing’s mechanism in biological systems represented by reaction-diffusion or reaction-cross-diffusion models have been extensively studied. Nonetheless, the impact of tissue stratification in such systems is under-explored, despite its ubiquity in the context of a thin epithelium overlying connective tissue, for instance the epidermis and underlying dermal mesenchyme of embryonic skin. In particular, each layer can be subject to extensively different biochemical reactions and transport processes, with chemotaxis - a special case of cross-diffusion - often present in the mesenchyme, contrasting the solely molecular transport typically found in the epidermal layer. We study Turing patterning conditions for a class of reaction-cross-diffusion systems in bilayered regions, with a thin upper layer and coupled by a linear transport law. In particular, the role of differential transport through the interface is explored together with the presence of asymmetry between the homogeneous equilibria of the two layers. A linear stability analysis is carried out around a spatially homogeneous equilibrium state in the asymptotic limit of weak and strong coupling strengths, where quantitative approximations of the bifurcation curve can be computed. Our theoretical findings, for an arbitrary number of reacting species, reveal quantitative Turing conditions, highlighting when the coupling mechanism between the layered regions can either trigger patterning or stabilize a spatially homogeneous equilibrium regardless of the independent patterning state of each layer. We support our theoretical results through direct numerical simulations, and provide an open source code to explore such systems further. | en |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | en |
dc.rights | © The Author(s) 2023 | en |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | Turing instabilities | en |
dc.subject | Stratified systems | en |
dc.subject | Skin patterns | en |
dc.subject | Interface | en |
dc.subject | Chemotaxis | en |
dc.title | Turing Pattern Formation in Reaction-Cross-Diffusion Systems with a Bilayer Geometry | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Bulletin of Mathematical Biology | en |
dc.identifier.volume | 86 | - |
dc.identifier.issue | 2 | - |
dc.relation.doi | 10.1007/s11538-023-01237-1 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 13 | - |
dc.identifier.pmid | 38170298 | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 22H05110 | - |
datacite.awardNumber | 17KK0094 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22H05110/ | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17KK0094/ | - |
dc.identifier.pissn | 0092-8240 | - |
dc.identifier.eissn | 1522-9602 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 生命の「かたち」と「うごき」の包括的理解と新たなデータ生命科学の創出 | ja |
jpcoar.awardTitle | 細胞の空間制御による時間制御の仕組み解明及びパターン形成の新たな理論創出 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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