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タイトル: | 骨転移を有する去勢感受性前立腺癌における骨シンチグラフィ評価指標Bone scan index(BSI)の有用性の検討 |
その他のタイトル: | Role of Bone Scan Index (BSI) in the Prognosis and Treatment Efficacy in Castration-Sensitive Prostate Cancer Patients with Bone Metastasis |
著者: | 出口, 佳穂 ![]() 佐々木, 豪 ![]() 大植, 裕之 ![]() 岡本, 尭 ![]() 加藤, 桃子 ![]() 梶原, 進也 ![]() 東, 真一郎 ![]() 舛井, 覚 ![]() 西川, 晃平 ![]() 井上, 貴博 ![]() |
著者名の別形: | DEGUCHI, Kaho SASAKI, Takeshi OUE, Hiroyuki OKAMOTO, Takashi KATO, Momoko KAJIWARA, Shinya HIGASHI, Shinichiro MASUI, Satoru NISHIKAWA, Kouhei INOUE, Takahiro |
キーワード: | Prostate cancer Bone metastasis Bone scan index |
発行日: | 29-Feb-2024 |
出版者: | 泌尿器科学術研究会 |
誌名: | 泌尿器科紀要 |
巻: | 70 |
号: | 2 |
開始ページ: | 29 |
終了ページ: | 37 |
抄録: | Bone is the most common metastatic site in prostate cancer (PCa). Although the extent of disease (EOD) grade is used for evaluating burden of bone metastasis, the accuracy of bone metastasis classification needs improvement. Bone scan index (BSI) was developed as a quantitative tool to enhance the interpretability and clinical relevance of the bone scan. This study aimed to explore the role of BSI using BONENAVI® software in determining the prognosis and treatment efficacy in castration-sensitive PCa (mCSPC) patients with bone metastasis. We retrospectively reviewed 61 mCSPC patients with bone metastasis who had received primary androgen deprivation therapy (PADT) at our institution. All patients received PADT with luteinizing hormone-releasing hormone agonist or surgical castration accompanied by first-generation antiandrogen, bicalutamide. Bone scans were performed with ⁹⁹[m]Tc-MDP. BSI (%) was divided into two groups (<1.0 and ≧1.0), and BSI response rates(change at 0 months to after 6 months) were determined using thresholds of 45% decline. Castration-resistant prostate cancer (CRPC) -free survival (CRPC-FS) and Overall survival (OS) rates were analyzed using the Kaplan-Meier method. The median follow-up was 41. 9 months. Overall, 16 patients (26. 2%) died. Multivariate analysis on pretreatment factors revealed that hemoglobin (P=0.03) and BSI (P=0.04) were independent prognostic factors for OS. The 5-year OS rates in patients with low BSI and high BSI were 84.6% and 39.2%, respectively (P=0.02). In 40 patients who had a bone scan before and after PADT, OS rates in patients with a good response (≧45%) were significantly higher than those with a poor response (<45%) (P=0.001). Nadir PSA titers within 6 months after the start of treatment (P=0.005), Hb (P=0.003), and BSI change (P=0.014) were independent prognostic factors for OS. In mCSPC patients with bone metastases, BSI at diagnosis was an important predictor of CRPC progression and OS as a pre-treatment factor, and BSI change rate and PSA nadir as post-treatment factors. |
著作権等: | 許諾条件により本文は2025-03-01に公開 |
DOI: | 10.14989/ActaUrolJap_70_2_29 |
URI: | http://hdl.handle.net/2433/287251 |
PubMed ID: | 38447942 |
出現コレクション: | Vol.70 No.2 |
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