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タイトル: | Visualizing Formation and Dynamics of a Three-Dimensional Sponge-like Network of a Coacervate in Real Time |
著者: | Kubota, Ryou Hiroi, Taro Ikuta, Yuriki Liu, Yuchong Hamachi, Itaru |
著者名の別形: | 窪田 亮 廣井 太郎 生田 優力 劉 宇翀 浜地 格 |
キーワード: | Alcohols Chemical structure Fluorescence Liquids Phase transitions |
発行日: | 23-Aug-2023 |
出版者: | American Chemical Society (ACS) |
誌名: | Journal of the American Chemical Society |
巻: | 145 |
号: | 33 |
開始ページ: | 18316 |
終了ページ: | 18328 |
抄録: | Coacervates, which are formed by liquid–liquid phase separation, have been extensively explored as models for synthetic cells and membraneless organelles, so their in-depth structural analysis is crucial. However, both the inner structure dynamics and formation mechanism of coacervates remain elusive. Herein, we demonstrate real-time confocal observation of a three-dimensional sponge-like network in a dipeptide-based coacervate. In situ generation of the dipeptide allowed us to capture the emergence of the sponge-like network via unprecedented membrane folding of vesicle-shaped intermediates. We also visualized dynamic fluctuation of the network, including reversible engagement/disengagement of cross-links and a stochastic network kissing event. Photoinduced transient formation of a multiphase coacervate was achieved with a thermally responsive phase transition. Our findings expand the fundamental understanding of synthetic coacervates and provide opportunities to manipulate their physicochemical properties by engineering the inner network for potential applications in development of artificial cells and life-like material fabrication. |
著作権等: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in 'Journal of the American Chemical Society', copyright © 2023 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/jacs.3c03793 The full-text file will be made open to the public on August 10, 2024 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/287522 |
DOI(出版社版): | 10.1021/jacs.3c03793 |
PubMed ID: | 37562059 |
出現コレクション: | 学術雑誌掲載論文等 |
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